Environmentally friendly method for the determination of acrylamide and trimethylolpropane in paper packaging materials by liquid chromatography with tandem mass spectrometry

• Published in: Journal of separation science 2014-12, Vol.37 (24), p.3625-3631
• Main Authors: Yang, Fei, Li, Zhonghao, Bian, Zhaoyang, Tang, Gangling, Fan, Ziyan, Wang, Ying, Liu, ShanShan, Zhang, Hongfei
• Format: Article
• Language: English
• Subjects: Acrylamide; Acrylamide - analysis; Analytical chemistry; Application fields; Applied sciences; Calibration; Chemistry; Chromatographic methods and physical methods associated with chromatography; Chromatography; Chromatography, Liquid; Exact sciences and technology; Food Packaging; Liquid chromatography; Mass spectrometry; Materials science; Other chromatographic methods; Packaging; Paper, paperboard, non wovens; Polymer industry, paints, wood; Propylene Glycols - analysis; Separation; Standard deviation; Tandem Mass Spectrometry; Technology of polymers; Trimethylolpropane; Wood. Paper. Non wovens
• ISSN: 1615-9306; 1615-9314
• DOI: 10.1002/jssc.201400504

A simple, rapid, and environmentally friendly method was developed for the determination of acrylamide and trimethylolpropane in paper packaging materials. No organic solvent was used and the matrix effect was investigated. The extract was directly analyzed by liquid chromatography with tandem mass chromatography for quantification and confirmation. The chromatographic separations were performed on a ZORBAX HILIC Plus (2.1 mm × 150 mm, 3μm; Agilent, USA) column with only one mobile phase (100% water). Calibration curves for acrylamide and trimethylopropane were achieved with concentrations ranging from 0.4 to 20 mg/kg and the corresponding r2 values were 0.998 and 0.999, respectively. The recoveries were >85% with relative standard deviations