Towards the Development of Smart 3D "Gated Scaffolds" for On-Command Delivery

A new approach towards the design of “gated scaffolds” based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin‐based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2014-12, Vol.10 (23), p.4859-4864
Main Authors: Mas, Núria, Arcos, Daniel, Polo, Lorena, Aznar, Elena, Sánchez-Salcedo, Sandra, Sancenón, Félix, García, Ana, Marcos, M. Dolores, Baeza, Alejandro, Vallet-Regí, María, Martínez-Máñez, Ramón
Format: Article
Language:English
Subjects:
3D scaffolds
Adenosine Triphosphate - chemistry
Anions
Biocompatible Materials - chemistry
Biomaterials
Biomedical materials
Capping
controlled release
Drug Carriers
Drug Delivery Systems
Enzymes
Gels - chemistry
Hydrogen Bonding
Imaging, Three-Dimensional - methods
Materials Testing
mesoporous silica nanoparticles
Microscopy, Electron, Scanning
Nanoparticles
Nanoparticles - chemistry
Nanotechnology
Nanotechnology - methods
Porosity
Regeneration
Scaffolds
Silicon Dioxide - chemistry
Surgical implants
Three dimensional
Tissue Engineering - methods
X-Ray Diffraction
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Summary:A new approach towards the design of “gated scaffolds” based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin‐based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and tested. This new design opens up the possibility of developing new smart biomaterials with advanced drug‐delivery features.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201401227