Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis

Highlights • Prenatal caffeine ingestion inhibits corticosterone production in fetal adrenal. • Prenatal caffeine ingestion inhibits SF-1 and steroidogenic enzymes expression. • Prenatal caffeine ingestion induces abberant DNA methylation of SF-1 promoter. • Prenatal caffeine ingestion induces abber...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2014-07, Vol.321, p.53-61
Main Authors: Ping, Jie, Wang, Jian-fei, Liu, Lian, Yan, You-e, Liu, Fang, Lei, You-ying, Wang, Hui
Format: Article
Language:English
Subjects:
Acetylation
Adrenal Glands - drug effects
Adrenal Glands - embryology
Adrenal Glands - metabolism
Animals
Anti-Inflammatory Agents - pharmacology
Caffeine
Caffeine - toxicity
Central Nervous System Stimulants - toxicity
Chromatin Immunoprecipitation
Corticosterone - pharmacology
Deoxyribonucleic acid
DNA methylation
DNA Methylation - drug effects
Emergency
Enzymes
Epigenesis, Genetic - drug effects
Female
Fetal adrenal
Gene expression
Histone acetylation
Histones
Histones - metabolism
Immunohistochemistry
Ingestion
Intrauterine growth retardation (IUGR)
Methylation
Pregnancy
Rats
Rats, Wistar
Real-Time Polymerase Chain Reaction
RNA
Steroidogenic Factor 1 - metabolism
Steroidogenic factor-1 (SF-1)
Steroids - biosynthesis
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Summary:Highlights • Prenatal caffeine ingestion inhibits corticosterone production in fetal adrenal. • Prenatal caffeine ingestion inhibits SF-1 and steroidogenic enzymes expression. • Prenatal caffeine ingestion induces abberant DNA methylation of SF-1 promoter. • Prenatal caffeine ingestion induces abberant histone acetylation of SF-1 promoter.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2014.03.011