Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it...

Full description

Saved in:
Bibliographic Details
Published in:Advanced materials (Weinheim) 2014-12, Vol.26 (45), p.7615-7621
Main Authors: Sun, Qihang, Sun, Xuanrong, Ma, Xinpeng, Zhou, Zhuxian, Jin, Erlei, Zhang, Bo, Shen, Youqing, Van Kirk, Edward A., Murdoch, William J., Lott, Joseph R., Lodge, Timothy P., Radosz, Maciej, Zhao, Yuliang
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
biomedical applications
Blood
Cancer
Cascades
Cell Line, Tumor
Cell Membrane - drug effects
Cell Membrane - metabolism
Cholesterol - chemistry
Clusters
Dendrimers
Doxorubicin - administration & dosage
drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Effectiveness
Female
Humans
lipids
Mice
Mice, Nude
Micelles
nanomedicine
Nanomedicine - methods
Nanostructure
Nanostructures - chemistry
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - metabolism
Phosphatidylethanolamines - chemistry
Polyethylene Glycols - chemistry
self-assembly
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like “bomblets”, enabling tumor penetration, cell internalization, and drug release.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201401554