Effect of l-Histidine Substitution on Sol–Gel of Transition Metal Coordinated Poly Ethyleneimine: Synthesis and Biochemical Characterization

The study was aimed to investigate the effect of chemical modification of branched poly ethyleneimine (PEI) on chelation of transition metal ions (Me 2+ ) including Zn 2+ , Cu 2+ or Ni 2+ and sol–gel conversion thereof. To modulate chelation property of PEI, imidazole moieties were introduced into t...

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Bibliographic Details
Published in:Journal of inorganic and organometallic polymers and materials 2014-11, Vol.24 (6), p.977-987
Main Authors: Abolmaali, Samira Sadat, Tamaddon, Ali, Najafi, Haniye, Dinarvand, Rasoul
Format: Article
Language:English
Subjects:
Chelation
Chemistry
Chemistry and Materials Science
Imidazole
Inorganic Chemistry
Nanostructure
Organic Chemistry
Polyetherimides
Polymer Sciences
Sol gel process
Spectroscopy
Synthesis
Transition metals
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Summary:The study was aimed to investigate the effect of chemical modification of branched poly ethyleneimine (PEI) on chelation of transition metal ions (Me 2+ ) including Zn 2+ , Cu 2+ or Ni 2+ and sol–gel conversion thereof. To modulate chelation property of PEI, imidazole moieties were introduced into the polymer backbone by carbodiimide chemistry at different molar ratios of fmoc-protected l -histidine. The synthesis was characterized by 1 H-NMR spectroscopy and size exclusion chromatography. Potentiometric titration of PEI/Me 2+ aqueous dispersions showed formation of stable complexes at pH above 5 depending on the degree of l -histidine substitution. FT-IR spectroscopy showed the imidazole ring of l -histidine was involved in the coordination interactions between PEI and Me 2+ . Addition of Zn 2+ to PEI solution induced sol–gel conversion at a critical molar ratio decreasing by a higher degree of l -histidine modification. The gelation process led to formation of stable globular nanostructures as confirmed by atomic force microscopy with projected mean diameters less than 200 nm. Cellular experiment showed that l -histidine substitution enhanced cyto-compatibility of PEI, moreover cytotoxicity decreased significantly upon coordination of Zn 2+ with the polymers. Conclusively, the coordination complexes of Zn 2+ and l -histidine substituted PEI could serve as a nano system for biomedical applications.
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-014-0067-3