Possible regulatory role of dynorphin A in the urinary bladder

In vitro, dynorphin A (1-13) strongly facilitated detrusor contraction induced by electrical field stimulation (EFS). This facilitation was counteracted by morphine and naloxone in a competitive manner. The facilitation could also be counteracted by the addition of the Kappa -receptor antagonist Mr2...

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Bibliographic Details
Published in:Journal of Neural Transmission 1992-01, Vol.90 (1), p.33-44
Main Authors: BERGGREN, A, DAHLSTRÖM, A, RUBENSON, A, SILLEN, U
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Vertebrates: urinary system
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Summary:In vitro, dynorphin A (1-13) strongly facilitated detrusor contraction induced by electrical field stimulation (EFS). This facilitation was counteracted by morphine and naloxone in a competitive manner. The facilitation could also be counteracted by the addition of the Kappa -receptor antagonist Mr2266. Muscarinic blockade, achieved with atropine, did not alter the effect of dynorphin A (1-13). Addition of phentolamine mesylate, and propranolol per se facilitated the EFS-induced contractions. Both adrenergic blockade as well as the addition of the substance P blocker spantide, counteracted the facilitating effect of dynorphin A (1-13). In conclusion: Dynorphin A immunoreactive material was found to be present in nerves in the rat detrusor and in prevesical ganglia. Dynorphin A (1-13) facilitated the detrusor contraction, possibly via actions on Kappa -opioid receptors and interaction with non-cholinergic nerves.
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01250516