Readily Prepared Dynamic Hydrogels by Combining Phenyl Boronic Acid- and Maltose-Modified Anionic Polysaccharides at Neutral pH

Dynamic covalent hydrogels are facilely prepared from biocompatible polysaccharides in physiological conditions by the formation of phenylboronate ester cross‐links. This is based on the simple mixing of carboxylate‐containing polysaccharides (i.e., hyaluronic acid or carboxymethylcellulose) modifie...

Full description

Saved in:
Bibliographic Details
Published in:Macromolecular rapid communications. 2014-12, Vol.35 (24), p.2089-2095
Main Authors: Tarus, Dominte, Hachet, Emilie, Messager, Léa, Catargi, Bogdan, Ravaine, Valérie, Auzély-Velty, Rachel
Format: Article
Language:English
Subjects:
Anions
Applied sciences
Aqueous solutions
Boronic Acids - chemistry
Calorimetry
Crosslinking
dynamic covalent hydrogels
Dynamics
Elastic Modulus
Esters
Exact sciences and technology
Formations
hyaluronic acid
Hyaluronic Acid - chemistry
Hydrogels
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogen-Ion Concentration
Joining
Maltose - chemistry
Natural polymers
phenylboronate esters
Physicochemistry of polymers
Polysaccharides
Polysaccharides - chemistry
Rheology
Starch and polysaccharides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dynamic covalent hydrogels are facilely prepared from biocompatible polysaccharides in physiological conditions by the formation of phenylboronate ester cross‐links. This is based on the simple mixing of carboxylate‐containing polysaccharides (i.e., hyaluronic acid or carboxymethylcellulose) modified with phenylboronic acid and maltose moieties according to mild coupling reactions performed in aqueous solution. The formation of dynamic networks based on reversible boronic‐ester cross‐links is demonstrated by analyzing their rheological behavior. This study shows that these gels can adapt their structure in response to chemical stimuli such as variations in pH or addition of glucose and self‐heal. A convenient method to prepare dynamic hydrogels from biocompatible anionic polysaccharides in physiological conditions by formation of phenylboronate ester cross‐links is described. The hydrogels are prepared under mild conditions from polysaccharide precursors that are synthesized using efficient coupling reactions in water. This concept can be applied to various carboxylate‐containing poly­saccharides, giving access to new classes of self‐healing polysaccharide materials.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201400477