Metabolic modeling of fumaric acid production by Rhizopus arrhizus

A metabolic mode is developed for fumaric acid production by Rhizopus arrhizus . The model describes the reaction network and the extents of reaction in terms of the concentrations of the measurable species. The proposed pathway consists of the Embden-Meyerhof pathway and two pathways to FA producti...

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Bibliographic Details
Published in:Applied biochemistry and biotechnology 1991-01, Vol.28, p.471-486
Main Authors: Gangl, I.C. (Illinois Institute of Technology, Chicago, IL), Weigand, W.A, Keller, F.A
Format: Article
Language:English
Subjects:
ACIDE ORGANIQUE
ACIDOS ORGANICOS
BIOCHEMICAL PATHWAYS
Biological and medical sciences
BIOLOGICAL PRODUCTION
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
ORGANIC ACIDS
RHIZOPUS
Rhizopus arrhizus
VIA BIOQUIMICA DEL METABOLISMO
VOIE BIOCHIMIQUE DU METABOLISME
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Summary:A metabolic mode is developed for fumaric acid production by Rhizopus arrhizus . The model describes the reaction network and the extents of reaction in terms of the concentrations of the measurable species. The proposed pathway consists of the Embden-Meyerhof pathway and two pathways to FA production, both of which require CO sub(2) fixation (the forward and the reverse TCA cycles). Relationships among the measurable quantities, in addition to those obtainable by a macroscopic mas balance, are found by invoking a pseudo-steady-state assumption on the nonaccumulating species in the pathway. Applications of the metabolic model, such as verifying the proposed pathway, obtaining the theoretical yield and selectivity, and detecting experimental errors, are discussed.
ISSN:0273-2289
1559-0291
DOI:10.1007/BF02922626