Developmental effects of methylated arsenic metabolites in mice

Mated female rats were treated with sodium dimethylarsinate or disodium methanearsonate, and developmental effects in offspring were examined. Results showed that both arsenic metabolites induced prenatal mortality and malformations in the developing offspring following ip maternal treatment on sing...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1998-08, Vol.61 (2), p.231-238
Main Author: Hood, R.D. (The University of Alabama, Tuscaloosa, AL.)
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - etiology
Animals
ARSENIC COMPOUNDS
Arsenic Poisoning
Arsenicals - metabolism
Biological and medical sciences
COMPOSE ARSENICAL
COMPUESTOS ARSENICALES
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Embryonic and Fetal Development - drug effects
Female
Fetal Death - chemically induced
Fundamental and applied biological sciences. Psychology
Infusions, Parenteral
METABOLITE
METABOLITES
METABOLITOS
Methylation
Mice
Pregnancy
Succimer - toxicity
Teratology. Teratogens
TOXICIDAD
TOXICITE
TOXICITY
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Description
Summary:Mated female rats were treated with sodium dimethylarsinate or disodium methanearsonate, and developmental effects in offspring were examined. Results showed that both arsenic metabolites induced prenatal mortality and malformations in the developing offspring following ip maternal treatment on single gestation days. Skeletal and neural tube defects were induced in offspring, but only at doses that were in or near the maternally toxic range.
ISSN:0007-4861
1432-0800
DOI:10.1007/s001289900753