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Developmental effects of methylated arsenic metabolites in mice
Mated female rats were treated with sodium dimethylarsinate or disodium methanearsonate, and developmental effects in offspring were examined. Results showed that both arsenic metabolites induced prenatal mortality and malformations in the developing offspring following ip maternal treatment on sing...
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| Published in: | Bulletin of environmental contamination and toxicology 1998-08, Vol.61 (2), p.231-238 |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c401t-8313ba4fc144462d85e68f3a5c5ae70257d8604ee25814b88ca2fa10048094013 |
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| container_end_page | 238 |
| container_issue | 2 |
| container_start_page | 231 |
| container_title | Bulletin of environmental contamination and toxicology |
| container_volume | 61 |
| creator | Hood, R.D. (The University of Alabama, Tuscaloosa, AL.) |
| description | Mated female rats were treated with sodium dimethylarsinate or disodium methanearsonate, and developmental effects in offspring were examined. Results showed that both arsenic metabolites induced prenatal mortality and malformations in the developing offspring following ip maternal treatment on single gestation days. Skeletal and neural tube defects were induced in offspring, but only at doses that were in or near the maternally toxic range. |
| doi_str_mv | 10.1007/s001289900753 |
| format | article |
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Skeletal and neural tube defects were induced in offspring, but only at doses that were in or near the maternally toxic range.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s001289900753</identifier><identifier>PMID: 9702361</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Abnormalities, Drug-Induced - etiology ; Animals ; ARSENIC COMPOUNDS ; Arsenic Poisoning ; Arsenicals - metabolism ; Biological and medical sciences ; COMPOSE ARSENICAL ; COMPUESTOS ARSENICALES ; Dose-Response Relationship, Drug ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic and Fetal Development - drug effects ; Female ; Fetal Death - chemically induced ; Fundamental and applied biological sciences. Psychology ; Infusions, Parenteral ; METABOLITE ; METABOLITES ; METABOLITOS ; Methylation ; Mice ; Pregnancy ; Succimer - toxicity ; Teratology. 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(The University of Alabama, Tuscaloosa, AL.)</creatorcontrib><title>Developmental effects of methylated arsenic metabolites in mice</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><description>Mated female rats were treated with sodium dimethylarsinate or disodium methanearsonate, and developmental effects in offspring were examined. Results showed that both arsenic metabolites induced prenatal mortality and malformations in the developing offspring following ip maternal treatment on single gestation days. 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Psychology</subject><subject>Infusions, Parenteral</subject><subject>METABOLITE</subject><subject>METABOLITES</subject><subject>METABOLITOS</subject><subject>Methylation</subject><subject>Mice</subject><subject>Pregnancy</subject><subject>Succimer - toxicity</subject><subject>Teratology. 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Psychology</topic><topic>Infusions, Parenteral</topic><topic>METABOLITE</topic><topic>METABOLITES</topic><topic>METABOLITOS</topic><topic>Methylation</topic><topic>Mice</topic><topic>Pregnancy</topic><topic>Succimer - toxicity</topic><topic>Teratology. Teratogens</topic><topic>TOXICIDAD</topic><topic>TOXICITE</topic><topic>TOXICITY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hood, R.D. 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| identifier | ISSN: 0007-4861 |
| ispartof | Bulletin of environmental contamination and toxicology, 1998-08, Vol.61 (2), p.231-238 |
| issn | 0007-4861 1432-0800 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16516345 |
| source | Springer Link |
| subjects | Abnormalities, Drug-Induced - etiology Animals ARSENIC COMPOUNDS Arsenic Poisoning Arsenicals - metabolism Biological and medical sciences COMPOSE ARSENICAL COMPUESTOS ARSENICALES Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Female Fetal Death - chemically induced Fundamental and applied biological sciences. Psychology Infusions, Parenteral METABOLITE METABOLITES METABOLITOS Methylation Mice Pregnancy Succimer - toxicity Teratology. Teratogens TOXICIDAD TOXICITE TOXICITY |
| title | Developmental effects of methylated arsenic metabolites in mice |
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