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The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid
Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on cotransfection of expression plasmids for th...
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| Published in: | The Journal of biological chemistry 1992-09, Vol.267 (27), p.19051-19053 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c506t-95246227cb2470b0bbb55f141117173f9df7e212d82a21b67ab752970397703 |
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| cites | cdi_FETCH-LOGICAL-c506t-95246227cb2470b0bbb55f141117173f9df7e212d82a21b67ab752970397703 |
| container_end_page | 19053 |
| container_issue | 27 |
| container_start_page | 19051 |
| container_title | The Journal of biological chemistry |
| container_volume | 267 |
| creator | SCOTT MUERHOFF, A GRIFFIN, K. J JOHNSON, E. F |
| description | Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase
expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on
cotransfection of expression plasmids for the peroxisome proliferator-activated receptor, PPAR. Activation by PPAR is observed
in the absence of the inducers. However, a mutant, PPAR-G (Glu282---Gly) activated luciferase expression only in the presence
of peroxisome proliferators. Deletion analysis has localized a response element to a 34-base pair segment located 677 base
pairs upstream of the CYP4A6 transcription start site that is similar to an element that regulates the response of the rat
fatty acyl-CoA oxidase gene to peroxisome proliferators and that binds PPAR. |
| doi_str_mv | 10.1016/s0021-9258(18)41738-3 |
| format | article |
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expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on
cotransfection of expression plasmids for the peroxisome proliferator-activated receptor, PPAR. Activation by PPAR is observed
in the absence of the inducers. However, a mutant, PPAR-G (Glu282---Gly) activated luciferase expression only in the presence
of peroxisome proliferators. Deletion analysis has localized a response element to a 34-base pair segment located 677 base
pairs upstream of the CYP4A6 transcription start site that is similar to an element that regulates the response of the rat
fatty acyl-CoA oxidase gene to peroxisome proliferators and that binds PPAR.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/s0021-9258(18)41738-3</identifier><identifier>PMID: 1326542</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Clofibric Acid - pharmacology ; Cloning, Molecular ; Cytochrome P-450 CYP4A ; Cytochrome P-450 Enzyme System - biosynthesis ; Cytochrome P-450 Enzyme System - genetics ; Cytochrome P-450 Enzyme System - metabolism ; Enzyme Induction - drug effects ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Mice ; Microbodies - physiology ; Mixed Function Oxygenases - biosynthesis ; Mixed Function Oxygenases - genetics ; Mixed Function Oxygenases - metabolism ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Promoter Regions, Genetic ; Receptors, Cell Surface - genetics ; Receptors, Cytoplasmic and Nuclear ; Regulatory Sequences, Nucleic Acid ; Transcription Factors - genetics ; Transfection</subject><ispartof>The Journal of biological chemistry, 1992-09, Vol.267 (27), p.19051-19053</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-95246227cb2470b0bbb55f141117173f9df7e212d82a21b67ab752970397703</citedby><cites>FETCH-LOGICAL-c506t-95246227cb2470b0bbb55f141117173f9df7e212d82a21b67ab752970397703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4332076$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1326542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCOTT MUERHOFF, A</creatorcontrib><creatorcontrib>GRIFFIN, K. J</creatorcontrib><creatorcontrib>JOHNSON, E. F</creatorcontrib><title>The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase
expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on
cotransfection of expression plasmids for the peroxisome proliferator-activated receptor, PPAR. Activation by PPAR is observed
in the absence of the inducers. However, a mutant, PPAR-G (Glu282---Gly) activated luciferase expression only in the presence
of peroxisome proliferators. Deletion analysis has localized a response element to a 34-base pair segment located 677 base
pairs upstream of the CYP4A6 transcription start site that is similar to an element that regulates the response of the rat
fatty acyl-CoA oxidase gene to peroxisome proliferators and that binds PPAR.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Clofibric Acid - pharmacology</subject><subject>Cloning, Molecular</subject><subject>Cytochrome P-450 CYP4A</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>Cytochrome P-450 Enzyme System - genetics</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Enzyme Induction - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Mice</subject><subject>Microbodies - physiology</subject><subject>Mixed Function Oxygenases - biosynthesis</subject><subject>Mixed Function Oxygenases - genetics</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Promoter Regions, Genetic</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cytoplasmic and Nuclear</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>Transcription Factors - genetics</subject><subject>Transfection</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNpFkd9qFDEUxoModa0-QiEXIgodzcnfmcuytCoULLQXehWSTNKJzGzWZFad1_CJzXaXNhfJ4Zzfdw75DkJnQD4CAfmpEEKh6aho30P7gYNibcOeoRWQljVMwPfnaPWIvESvSvlJ6uEdnKATYFQKTlfo393g8dbn9DeWNNUwpzEGn82ccmPcHH-b2fc4e-e3NYUn38eaKXiuurjpdxVJG5wCXv-44RfyHBvsljm5Ie_b3XBBcDDzvGDjYo9r7t40w9LXgctoij_HdsFuTCHaHN0D9Bq9CGYs_s3xPUW3V5d36y_N9bfPX9cX140TRM5NJyiXlCpnKVfEEmutEAE4AKhqRuj6oDwF2rfUULBSGasE7RRhnarXKXp36Fp__Gvny6ynWJwfR7PxaVc0SAGK07aC4gC6nErJPuhtjpPJiwai95vQt3ub9d5mDa1-2IRmVXd2HLCz1bUn1cH6Wn97rJvizBiy2bhYHjHOGCVKPmFDvB_-xOy1jdVdP2kqlaZKQ0cEsP8eYJzf</recordid><startdate>19920925</startdate><enddate>19920925</enddate><creator>SCOTT MUERHOFF, A</creator><creator>GRIFFIN, K. 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Psychology</topic><topic>Gene expression</topic><topic>Mice</topic><topic>Microbodies - physiology</topic><topic>Mixed Function Oxygenases - biosynthesis</topic><topic>Mixed Function Oxygenases - genetics</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Promoter Regions, Genetic</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cytoplasmic and Nuclear</topic><topic>Regulatory Sequences, Nucleic Acid</topic><topic>Transcription Factors - genetics</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCOTT MUERHOFF, A</creatorcontrib><creatorcontrib>GRIFFIN, K. J</creatorcontrib><creatorcontrib>JOHNSON, E. 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F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1992-09-25</date><risdate>1992</risdate><volume>267</volume><issue>27</issue><spage>19051</spage><epage>19053</epage><pages>19051-19053</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>Gene transfer experiments indicate that induction by the peroxisome proliferators, clofibric acid and WY-14,643, of luciferase
expression driven by the promoter and 5'-flanking sequences of the rabbit cytochrome P450 4A6 gene (CYP4A6) is dependent on
cotransfection of expression plasmids for the peroxisome proliferator-activated receptor, PPAR. Activation by PPAR is observed
in the absence of the inducers. However, a mutant, PPAR-G (Glu282---Gly) activated luciferase expression only in the presence
of peroxisome proliferators. Deletion analysis has localized a response element to a 34-base pair segment located 677 base
pairs upstream of the CYP4A6 transcription start site that is similar to an element that regulates the response of the rat
fatty acyl-CoA oxidase gene to peroxisome proliferators and that binds PPAR.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>1326542</pmid><doi>10.1016/s0021-9258(18)41738-3</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1992-09, Vol.267 (27), p.19051-19053 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | ScienceDirect (Online service) |
| subjects | Animals Base Sequence Biological and medical sciences Clofibric Acid - pharmacology Cloning, Molecular Cytochrome P-450 CYP4A Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Enzyme Induction - drug effects Fundamental and applied biological sciences. Psychology Gene expression Mice Microbodies - physiology Mixed Function Oxygenases - biosynthesis Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Receptors, Cell Surface - genetics Receptors, Cytoplasmic and Nuclear Regulatory Sequences, Nucleic Acid Transcription Factors - genetics Transfection |
| title | The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid |
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