TMC-49A, a Novel Transcriptional Up-Regulator of Low Density Lipoprotein Receptor, Produced by Streptomyces sp. AS1345

Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phene...

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Bibliographic Details
Published in:Journal of antibiotics 1998/02/25, Vol.51(2), pp.107-111
Main Authors: KOGUCHI, YUTAKA, ASAI, YASUYUKI, SUZUKI, SHIN-ICHI, NISHIO, MAKI, YANAKA, NORIYUKI, OMORI, KENJI, OHNUKI, TETSUO, KOMATSUBARA, SABURO
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Carbamates - chemistry
Carbamates - isolation & purification
Carbamates - pharmacology
Fermentation
Fundamental and applied biological sciences. Psychology
Humans
Metabolism. Enzymes
Microbiology
Receptors, LDL - biosynthesis
Receptors, LDL - drug effects
Receptors, LDL - metabolism
Streptomyces
Transcription, Genetic - drug effects
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - metabolism
Up-Regulation - drug effects
Urethane - analogs & derivatives
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Summary:Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49A was discovered as an up-regulator obtained from the fermentation broth of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phenethylcarbamate by spectroscopic analyses. This compound enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Taxonomy of the producing strain is also described.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.51.107