SERUM magnesium levels as an indicator of status of Diabetes Mellitus type 2

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2015-01, Vol.9 (1), p.42-45
• Main Authors: Ramadass, S, Basu, Sharbari, Srinivasan, A.R
• Format: Article
• Language: English
• Subjects: Adult; Analysis of Variance; Biomarkers - blood; Blood Glucose - metabolism; Diabetes Mellitus type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - epidemiology; Endocrinology & Metabolism; Fasting; Female; Glycated Hemoglobin A - metabolism; HbA1c; Humans; Hypomagnesemia; India - epidemiology; Magnesium - blood; Magnesium Deficiency - blood; Magnesium Deficiency - complications; Magnesium Deficiency - epidemiology; Male; Middle Aged; Nutrition Disorders - blood; Nutrition Disorders - complications; Nutrition Disorders - epidemiology; Predictive Value of Tests; Prognosis; Risk Factors; Time Factors
• ISSN: 1871-4021; 1878-0334
• DOI: 10.1016/j.dsx.2014.04.024

Abstract Context Magnesium deficiency is commonly associated with endocrine and metabolic disorders, especially with Diabetes Mellitus type 2 though the mechanism of hypomagnesemia in Diabetes Mellitus is not completely known. There is a close association between metabolic control of Diabetes Mellitus and impaired magnesium balance. Aims To estimate the serum levels of magnesium in patients of with Diabetes Mellitus type 2 and to find a correlation if any, with the duration and control (by estimating HbA1c) of Diabetes Mellitus type 2. Materials and methods Fifty patients of Diabetes Mellitus type 2 were included in the study. Blood samples were analyzed for fasting and post prandial glucose, HbA1c and magnesium. The patients were grouped into three categories based upon their HbA1c levels into those with good control, need intervention and poor control. The three groups were compared with reference to their mean levels of blood glucose and magnesium. Association of serum magnesium levels with HbA1c, Fasting and postprandial blood glucose and duration of Diabetes Mellitus was also done. Results Serum magnesium levels were found to decline with rise in HbA1c levels and with duration of Diabetes Mellitus type 2. Conclusion Hypomagnesemia is linked to poor control of Diabetes Mellitus type 2 and depletion of serum magnesium occurs exponentially with duration of disease.