Incidence of hospital admissions due to adverse drug reactions in France: the EMIR study

• Published in: Fundamental & clinical pharmacology 2015-02, Vol.29 (1), p.106-111
• Main Authors: Bénard-Laribière, Anne, Miremont-Salamé, Ghada, Pérault-Pochat, Marie-Christine, Noize, Pernelle, Haramburu, Françoise
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; adverse drug reactions; Aged; Anticoagulants - adverse effects; Drug Interactions; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - etiology; France; Hospitalization; Humans; Incidence; Middle Aged; pharmacovigilance; Prospective Studies; Young Adult
• ISSN: 0767-3981; 1472-8206
• DOI: 10.1111/fcp.12088

To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients admitted during a 2‐week period were included. An ADR‐related hospitalization case was defined as a hospital admission because of an ADR, and an independent committee reviewed and validated all potential cases. Preventability was assessed using the French ADR preventability scale. Data were extrapolated to the population of France. Among 2692 admissions, 97 were related to an ADR (incidence 3.6%, 95% confidence interval, CI [2.8–4.4]). Patients admitted for an ADR were significantly older than those admitted for other reasons (P