Detailed analysis of the density change on chest CT of COPD using non-rigid registration of inspiration/expiration CT scans

Objectives One objective was to evaluate the air trapping index (ATI), measured by inspiration/expiration CT, in COPD patients and nonsmokers. Another objective was to assess the association between the pulmonary function test (PFT) and CT parameters such as ATI or other indices, separately in the w...

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Bibliographic Details
Published in:European radiology 2015-02, Vol.25 (2), p.541-549
Main Authors: Kim, Eun Young, Seo, Joon Beom, Lee, Hyun Joo, Kim, Namkug, Lee, Eunsol, Lee, Sang Min, Oh, Sang Young, Hwang, Hye Jeon, Oh, Yeon-Mok, Lee, Sang-Do
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Airway management
Chest
Chronic obstructive pulmonary disease
Cohort analysis
Diagnostic Radiology
Emphysema
Exhalation
Female
Humans
Imaging
Inhalation
Internal Medicine
Interventional Radiology
Lung - diagnostic imaging
Lung - physiopathology
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Pulmonary Disease, Chronic Obstructive - diagnostic imaging
Pulmonary Disease, Chronic Obstructive - physiopathology
Radiography, Thoracic - methods
Radiology
Respiratory Function Tests
Retrospective Studies
Tomography, X-Ray Computed - methods
Ultrasound
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Summary:Objectives One objective was to evaluate the air trapping index (ATI), measured by inspiration/expiration CT, in COPD patients and nonsmokers. Another objective was to assess the association between the pulmonary function test (PFT) and CT parameters such as ATI or other indices, separately in the whole lung, in emphysema, and in hyperinflated and normal lung areas. Methods One hundred and thirty-eight COPD patients and 29 nonsmokers were included in our study. The ATI, the emphysema index (EI), the gas trapping index (Exp -856) and expiration/inspiration ratio of mean lung density (E/Iratio of MLD) were measured on CT. The values of the whole lung, of emphysema, and of hyperinflated and normal lung areas were compared and then correlated with various PFT parameters. Results Compared with nonsmokers, COPD patients showed a higher ATI in the whole lung and in each lung lesion (all P  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-014-3418-0