Outcomes of immediate perforator flap reconstruction after skin-sparing mastectomy following neoadjuvant chemotherapy

Abstract Background The impact of neoadjuvant chemotherapy (NACT) on immediate free flap breast reconstruction remains controversial. Furthermore, the oncological outcomes of immediate free flap breast reconstruction after skin-sparing mastectomy (SSM) following NACT remain unclear. This study aimed...

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Bibliographic Details
Published in:European journal of surgical oncology 2015-01, Vol.41 (1), p.94-99
Main Authors: Narui, K, Ishikawa, T, Satake, T, Adachi, S, Yamada, A, Shimada, K, Shimizu, D, Kida, K, Sugae, S, Ichikawa, Y, Tanabe, M, Sasaki, T, Endo, I
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal, Humanized - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - surgery
Carboplatin - therapeutic use
Carcinoma, Ductal, Breast - drug therapy
Carcinoma, Ductal, Breast - surgery
Carcinoma, Intraductal, Noninfiltrating - surgery
Carcinoma, Lobular - surgery
Chemotherapy, Adjuvant
Cohort Studies
Cyclophosphamide - therapeutic use
Epirubicin - therapeutic use
Etoposide - therapeutic use
Female
Fluorouracil - therapeutic use
Hematology, Oncology and Palliative Medicine
Humans
Immediate reconstruction
Mammaplasty - methods
Mastectomy, Subcutaneous - methods
Middle Aged
Neoadjuvant chemotherapy
Neoadjuvant Therapy
Paclitaxel - administration & dosage
Perforator Flap
Retrospective Studies
Surgery
Taxoids - administration & dosage
Trastuzumab
Treatment Outcome
Young Adult
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Summary:Abstract Background The impact of neoadjuvant chemotherapy (NACT) on immediate free flap breast reconstruction remains controversial. Furthermore, the oncological outcomes of immediate free flap breast reconstruction after skin-sparing mastectomy (SSM) following NACT remain unclear. This study aimed to investigate the surgical complications and oncological outcomes of immediate perforator flap reconstruction after SSM following NACT. Methods A total of 201 consecutive patients with indications for immediate perforator flap reconstruction after SSM were included between 2004 and 2012. Surgical and oncological outcomes were compared between patients with and without NACT. Results There were 38 patients in the NACT group and 163 in the non-NACT control group. The median age of the NACT group was 39.5 years, which was significantly younger than the control group (43.0 years; P  
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2014.09.001