Drug target miRNAs: chances and challenges

Highlights • miRNAs are high-potential drug targets. • Development of miRNA-targeting drugs is challenging due to their chemical structure comprising short ribonucleic acids. • Anti-sense agents targeting miRNAs have been successful when used in advanced formulations. • Small-molecule modulators tha...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2014-11, Vol.32 (11), p.578-585
Main Author: Schmidt, Marco F
Format: Article
Language:English
Subjects:
antisense agents
Biological and medical sciences
Biotechnology
Clinical trials
drug discovery
Drug Discovery - methods
Drug Discovery - trends
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - drug effects
Genes
Genetic engineering
Genomics
Humans
Internal Medicine
Kinases
Medical treatment
MicroRNAs - antagonists & inhibitors
MicroRNAs - metabolism
miRNA
miRNA-induced silencing complex
Molecular weight
Nanoparticles
Pharmaceutical industry
Pharmacology - methods
Pharmacology - trends
Proteins
RNAi
small molecule miRNA modulators
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Summary:Highlights • miRNAs are high-potential drug targets. • Development of miRNA-targeting drugs is challenging due to their chemical structure comprising short ribonucleic acids. • Anti-sense agents targeting miRNAs have been successful when used in advanced formulations. • Small-molecule modulators that bind to RNAi-involved proteins have good chances to become a new drug class.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2014.09.002