Role of islet β cell autophagy in the pathogenesis of diabetes

Highlights • β Cell autophagy is important for β cell mass, structure, and function. • β Cell autophagy level could be a factor in the progression from obesity to diabetes. • β Cell autophagy is important to prevent amyloidogenic hIAPP accumulation. • Autophagy enhancers may enhance β cell function...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2014-12, Vol.25 (12), p.620-627
Main Author: Lee, Myung-Shik
Format: Article
Language:English
Subjects:
autophagy
Autophagy - physiology
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Endocrinology & Metabolism
Endoplasmic Reticulum Stress - physiology
ER stress
Humans
Insulin-Secreting Cells - metabolism
Insulin-Secreting Cells - pathology
islet amyloid
Islet Amyloid Polypeptide - metabolism
obesity
β cell
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Summary:Highlights • β Cell autophagy is important for β cell mass, structure, and function. • β Cell autophagy level could be a factor in the progression from obesity to diabetes. • β Cell autophagy is important to prevent amyloidogenic hIAPP accumulation. • Autophagy enhancers may enhance β cell function and improve metabolic profile.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2014.08.005