CLIF-SOFA scoring system accurately predicts short-term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis

• Published in: Liver international 2015-01, Vol.35 (1), p.46-57
• Main Authors: Lee, Minjong, Lee, Jeong-Hoon, Oh, Sohee, Jang, Yoonhyuk, Lee, Wonik, Lee, Hyung Joo, Yoo, Jeong-ju, Choi, Won-Mook, Cho, Young Youn, Cho, Yuri, Lee, Dong Hyeon, Lee, Yun Bin, Yu, Su Jong, Yi, Nam-Joon, Lee, Kwang-Woong, Kim, Yoon Jun, Yoon, Jung-Hwan, Suh, Kyung-Suk, Lee, Hyo-Suk
• Format: Article
• Language: English
• Subjects: acute-on-chronic liver failure; Acute-On-Chronic Liver Failure - diagnosis; Acute-On-Chronic Liver Failure - etiology; Acute-On-Chronic Liver Failure - mortality; Area Under Curve; CLIF-SOFA; Female; Humans; Liver Cirrhosis, Alcoholic - complications; Male; Middle Aged; Organ Dysfunction Scores; Predictive Value of Tests; Prognosis; Republic of Korea; Retrospective Studies; ROC Curve; Statistics, Nonparametric; validation
• ISSN: 1478-3223; 1478-3231
• DOI: 10.1111/liv.12683

Background & Aims Accurate prognostication of acute‐on‐chronic liver failure (ACLF) is essential for therapeutic decisions. Our aim was to validate a novel scoring system for predicting mortality, the chronic liver failure‐sequential organ failure assessment (CLIF‐SOFA), in a population of Asian patients with ACLF. Methods A total of 345 patients with acutely decompensated alcoholic cirrhosis were selected for study, comparing areas under the receiver operating characteristic (AUROC) curves of CLIF‐SOFA and five existing scoring systems for end‐stage liver disease [model for end‐stage liver disease (MELD), MELD‐Na, Refit‐MELD, Refit‐MELD‐Na, and Child‐Turcotte‐Pugh]. Results CLIF‐SOFA displayed the highest AUROC of 0.943 significantly outperforming all five reference methods in predicting short‐term mortality at Week 4 (all P