Does arterial health affect VO2peak and muscle oxygenation in a sedentary cohort?

• Published in: Medicine and science in sports and exercise 2015-02, Vol.47 (2), p.272-279
• Main Authors: Lizamore, Catherine Anne, Stoner, Lee, Lucas, Samuel John Edwin, Lucero, Adam, Hamlin, Michael John
• Format: Article
• Language: English
• Subjects: Arteries - physiology; Exercise - physiology; Female; Humans; Male; Middle Aged; Muscle, Skeletal - blood supply; Muscle, Skeletal - physiology; Oxygen Consumption; Pulse Wave Analysis; Sedentary Lifestyle; Spectroscopy, Near-Infrared; Vascular Stiffness
• ISSN: 1530-0315
• DOI: 10.1249/MSS.0000000000000414

An association between arterial health and peak oxygen consumption (VO2peak) has been demonstrated; however, little is known about how arterial health influences muscular oxygenation during exercise. The aim of this study was to gain insight into the relations between arterial health, VO2peak, and muscle oxygenation in a middle-age sedentary population. Radial augmentation index (AIx) (via pulse wave analysis) of 21 sedentary middle-age participants (15 females and six males; age, 54.7 ± 5.4; body mass index, 29.0 ± 4.7 kg·m; mean ± SD) was assessed, and on another day ( < 7 d), participants completed a modified Bruce protocol (MBP). Using near-infrared spectroscopy, total oxygenation index (TOI) of the left flexor carpi ulnaris and the left vastus lateralis were monitored throughout the MBP. Independent and average (arm + leg) percentage decrease in TOI between stage 1 of the MBP and maximal exertion (TOIdiff) during MBP was calculated. Changes between dependent variables were correlated using Pearson product-moment correlations and were interpreted as follows: r > 0.5, strong; 0.5 > r > 0.3, moderate; and r < 0.3, weak. We observed moderate negative correlation between AIx and VO2peak (r = -0.34, -0.63 to -0.03; Pearson correlation, 90% confidence limits) and strong negative correlation between AIx and average TOIdiff (r = -0.58, -0.78 to -0.27). The VO2peak and average TOIdiff were strongly correlated (r = 0.55, 0.23-0.77). Arterial health seems to be an important determinant of muscle oxygenation during exercise. In turn, muscle oxygenation during exercise is strongly related to VO2peak. Developing training modalities to prioritize arterial health outcomes may be a useful way of improving VO2peak in this population.