Glycemic control after brain injury: Boon and bane for the brain

Highlights • Hyperglycemia is common in patients with BI. • Intensive glucose-lowering therapy results in an increased rate of hypoglycemia. • The acutely injured brain is prone to energetic undersupply. • Careful insulin application without an adherence to strict euglycemia seems beneficial for the...

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Bibliographic Details
Published in:Neuroscience 2014-12, Vol.283, p.202-209
Main Authors: Jauch-Chara, K, Oltmanns, K.M
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Brain - metabolism
Brain - pathology
Brain Injuries - complications
cerebral glucose metabolism
Humans
hyperglycemia
Hyperglycemia - drug therapy
Hyperglycemia - etiology
hypoglycemia
Hypoglycemic Agents - therapeutic use
Insulin - therapeutic use
insulin therapy
Neurology
stroke
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Summary:Highlights • Hyperglycemia is common in patients with BI. • Intensive glucose-lowering therapy results in an increased rate of hypoglycemia. • The acutely injured brain is prone to energetic undersupply. • Careful insulin application without an adherence to strict euglycemia seems beneficial for the injured brain.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.04.059