Intestinal metaplasia in Barrett's oesophagus may be an epiphenomenon rather than a preneoplastic condition, and CDX2-positive cardiac-type epithelium is associated with minute Barrett's tumour

Aims Although intestinal‐type epithelium in Barrett's oesophagus has been traditionally recognized as having a distinct malignant potential, whether this also holds true for cardiac‐type epithelium remains controversial. The aim of this study was to identify a type of epithelium that is highly...

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Bibliographic Details
Published in:Histopathology 2015-01, Vol.66 (2), p.201-214
Main Authors: Watanabe, Gen, Ajioka, Yoichi, Takeuchi, Manabu, Annenkov, Alexey, Kato, Takashi, Watanabe, Kaori, Tani, Yusuke, Ikegami, Kikuo, Yokota, Yoko, Fukuda, Mutsumi
Format: Article
Language:English
Subjects:
Aged
Barrett Esophagus - pathology
Barrett's oesophagus
Cardia - pathology
cardiac-type epithelium
CDX2
CDX2 Transcription Factor
Esophageal Neoplasms - pathology
Female
Homeodomain Proteins - metabolism
Humans
Immunohistochemistry
intestinal metaplasia
Intestinal Mucosa - pathology
Male
Metaplasia - pathology
Middle Aged
Mucous membrane
Precancerous Conditions - pathology
Retrospective Studies
Tumors
tumour immunophenotype
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Summary:Aims Although intestinal‐type epithelium in Barrett's oesophagus has been traditionally recognized as having a distinct malignant potential, whether this also holds true for cardiac‐type epithelium remains controversial. The aim of this study was to identify a type of epithelium that is highly associated with Barrett's tumour. Methods and results We analysed tumours and the corresponding background mucosa with special regard to tumour size in 40 cases of superficial Barrett's tumour by using immunohistochemical staining for CDX2, CD10, MUC2, MUC5AC, and MUC6. Intestinal metaplasia in tumour‐adjacent mucosa was not associated with tumour size, but was significantly correlated with the extent of Barrett's oesophagus (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.12486