Fibroblast growth factor receptor 2: a new potential therapeutic target for human cancer

[...]FGFR selective small molecule inhibitors or FGFR2 short hairpin RNA (shRNA) strongly inhibited cell viability in vitro. [...]these results suggest that emerging FGFR small molecule inhibitor therapeutics in clinical development might have efficacy in a subset of colon cancer driven by FGFR2 ove...

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Bibliographic Details
Published in:Human pathology 2015-02, Vol.46 (2), p.339-340
Main Authors: Cheng, Chang, MD, Hu, Wei, PhD, Liu, Li-Ping, MD, Li, Jun, PhD
Format: Article
Language:English
Subjects:
Bile Duct Neoplasms - genetics
Bile Ducts, Intrahepatic - metabolism
Cancer
Cholangiocarcinoma - genetics
Female
Humans
Kinases
Male
Medical diagnosis
Medical prognosis
Pathology
Receptor, Fibroblast Growth Factor, Type 2 - genetics
Rodents
Translocation, Genetic
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Summary:[...]FGFR selective small molecule inhibitors or FGFR2 short hairpin RNA (shRNA) strongly inhibited cell viability in vitro. [...]these results suggest that emerging FGFR small molecule inhibitor therapeutics in clinical development might have efficacy in a subset of colon cancer driven by FGFR2 overexpression or amplification [4].
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2014.10.012