Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection

Highlights • Functional SNPs in TLR3/7/8 and TIRAP genes were investigated in dengue cases and healthy controls. • Significantly lower frequency of TLR3 rs3775291T allele and higher frequency of TIRAP rs8177374 ‘C/T’ genotype was observed in DHF. • TLR3 and TIRAP gene variants influence the risk for...

Full description

Saved in:
Bibliographic Details
Published in:Immunobiology (1979) 2015-01, Vol.220 (1), p.164-168
Main Authors: Alagarasu, K, Bachal, R.V, Memane, R.S, Shah, P.S, Cecilia, D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advanced Basic Science
Alleles
Allergy and Immunology
Case-Control Studies
Computational Biology
Dengue
Dengue - genetics
Dengue - virology
Dengue fever
Dengue hemorrhagic fever
Dengue Virus
Female
Gene Frequency
Gene polymorphisms
Genotype
Humans
Male
Membrane Glycoproteins - genetics
Middle Aged
Patient Outcome Assessment
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prognosis
Receptors, Interleukin-1 - genetics
Toll like receptor
Toll-Like Receptors - genetics
Web Browser
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Functional SNPs in TLR3/7/8 and TIRAP genes were investigated in dengue cases and healthy controls. • Significantly lower frequency of TLR3 rs3775291T allele and higher frequency of TIRAP rs8177374 ‘C/T’ genotype was observed in DHF. • TLR3 and TIRAP gene variants influence the risk for DHF.
ISSN:0171-2985
1878-3279
DOI:10.1016/j.imbio.2014.09.020