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25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis
The objective of this study is to evaluate the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. We included patients with rheumatoid arthritis followed in Rheumatology Department of Hassan II...
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| Published in: | Clinical rheumatology 2015-02, Vol.34 (2), p.353-357 |
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| container_end_page | 357 |
| container_issue | 2 |
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| container_title | Clinical rheumatology |
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| creator | Abourazzak, F. E. Talbi, S. Aradoini, N. Berrada, K. Keita, S. Hazry, T. |
| description | The objective of this study is to evaluate the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. We included patients with rheumatoid arthritis followed in Rheumatology Department of Hassan II University Hospital, Fez, Morocco. Patients suffering from liver and kidney insufficiency and those who had received vitamin D in the previous 12 months have been excluded. Statistical analysis was done using SPSS v 18. A bivariate analysis and logistic regression were used to identify factors associated with vitamin D deficiency. One hundred seventy patients were included with a mean age of 50 ± 12.1 [17–83] years, and a female predominance (88.1 %). All of our patients had hypovitaminosis D. The prevalence of 25(OH)-D insufficiency and deficiency was 64.5 and 35.5 % successively. In unadjusted analysis, vitamin D concentration was inversely associated with pain visual analog scale VAS score (
p
|
| doi_str_mv | 10.1007/s10067-014-2713-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652400089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3569618331</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-74b8fcdf20b4ae6ffddb518576a6aed6679cbe8d4d1d6d80b2420c28b43887d33</originalsourceid><addsrcrecordid>eNp1kUtPAyEYRYnR2Fr9AW4MiRs3KDAUmKWpz6SJG10TZmAcmnkJjNp_L7VqjIkbWHDu4ct3ATgm-JxgLC5COrlAmDBEBckQ3gFTwjKG8pzlu2CKhcAoI7mcgIMQVhhjKnOyDyaU5ZRxLKbgjc5RvTa-f1_DVxd16zp4BXVnoIsBetvo6Pou1G6Aby7WsGxc50rdfCKNLnqvY-_XcNBetzZaH2AyDClluyT4zPjajm3CnIHax9q76MIh2Kt0E-zR1z0DTzfXj4s7tHy4vV9cLlHJGI1IsEJWpakoLpi2vKqMKeZEzgXXXFvDucjLwkrDDDHcSFxQRnFJZcEyKYXJshk423oH37-MNkTVulDaptGd7cegCJ9TlhYj84Se_kFX_ei7NF2imKQsrVYmimyp0vcheFupwbtW-7UiWG1aUdtWVGpFbVpROGVOvsxj0Vrzk_iuIQF0C4T01D1b_-vrf60fXRKZcw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1648241438</pqid></control><display><type>article</type><title>25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis</title><source>Springer Nature</source><creator>Abourazzak, F. E. ; Talbi, S. ; Aradoini, N. ; Berrada, K. ; Keita, S. ; Hazry, T.</creator><creatorcontrib>Abourazzak, F. E. ; Talbi, S. ; Aradoini, N. ; Berrada, K. ; Keita, S. ; Hazry, T.</creatorcontrib><description>The objective of this study is to evaluate the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. We included patients with rheumatoid arthritis followed in Rheumatology Department of Hassan II University Hospital, Fez, Morocco. Patients suffering from liver and kidney insufficiency and those who had received vitamin D in the previous 12 months have been excluded. Statistical analysis was done using SPSS v 18. A bivariate analysis and logistic regression were used to identify factors associated with vitamin D deficiency. One hundred seventy patients were included with a mean age of 50 ± 12.1 [17–83] years, and a female predominance (88.1 %). All of our patients had hypovitaminosis D. The prevalence of 25(OH)-D insufficiency and deficiency was 64.5 and 35.5 % successively. In unadjusted analysis, vitamin D concentration was inversely associated with pain visual analog scale VAS score (
p
< 0.001), asthenia VAS (
p
< 0.001), morning stiffness (
p
= 0.03), number of tender joints (
p
= 0.004), number of swollen joints (
p
< 0.001), inflammatory markers (
p
= 0,012), Disease Activity Score (
p
= 0.009), physical disability using Health Assessment Questionnaire (HAQ) (
p
= 0.001), and severity of the disease (
p
< 0.001). After logistic regression persisted association with female sex (OR = 4.3, CI = [0.94 to 20.976],
p
= 0.05), asthenia VAS (OR = 1.029, CI = [1.011 to 1.046],
p
= 0.001), and with the severity of the disease (OR = 2.910, CI = [1.314–6.441],
p
= 0.008). The vitamin D deficiency is common in our patients with RA. This deficiency is associated with female sex, severe asthenia, and the severity of the disease.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-014-2713-0</identifier><identifier>PMID: 24924607</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - complications ; Brief Report ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Prevalence ; Rheumatology ; Severity of Illness Index ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - epidemiology ; Young Adult</subject><ispartof>Clinical rheumatology, 2015-02, Vol.34 (2), p.353-357</ispartof><rights>Clinical Rheumatology 2014</rights><rights>International League of Associations for Rheumatology (ILAR) 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-74b8fcdf20b4ae6ffddb518576a6aed6679cbe8d4d1d6d80b2420c28b43887d33</citedby><cites>FETCH-LOGICAL-c442t-74b8fcdf20b4ae6ffddb518576a6aed6679cbe8d4d1d6d80b2420c28b43887d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24924607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abourazzak, F. E.</creatorcontrib><creatorcontrib>Talbi, S.</creatorcontrib><creatorcontrib>Aradoini, N.</creatorcontrib><creatorcontrib>Berrada, K.</creatorcontrib><creatorcontrib>Keita, S.</creatorcontrib><creatorcontrib>Hazry, T.</creatorcontrib><title>25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>The objective of this study is to evaluate the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. We included patients with rheumatoid arthritis followed in Rheumatology Department of Hassan II University Hospital, Fez, Morocco. Patients suffering from liver and kidney insufficiency and those who had received vitamin D in the previous 12 months have been excluded. Statistical analysis was done using SPSS v 18. A bivariate analysis and logistic regression were used to identify factors associated with vitamin D deficiency. One hundred seventy patients were included with a mean age of 50 ± 12.1 [17–83] years, and a female predominance (88.1 %). All of our patients had hypovitaminosis D. The prevalence of 25(OH)-D insufficiency and deficiency was 64.5 and 35.5 % successively. In unadjusted analysis, vitamin D concentration was inversely associated with pain visual analog scale VAS score (
p
< 0.001), asthenia VAS (
p
< 0.001), morning stiffness (
p
= 0.03), number of tender joints (
p
= 0.004), number of swollen joints (
p
< 0.001), inflammatory markers (
p
= 0,012), Disease Activity Score (
p
= 0.009), physical disability using Health Assessment Questionnaire (HAQ) (
p
= 0.001), and severity of the disease (
p
< 0.001). After logistic regression persisted association with female sex (OR = 4.3, CI = [0.94 to 20.976],
p
= 0.05), asthenia VAS (OR = 1.029, CI = [1.011 to 1.046],
p
= 0.001), and with the severity of the disease (OR = 2.910, CI = [1.314–6.441],
p
= 0.008). The vitamin D deficiency is common in our patients with RA. This deficiency is associated with female sex, severe asthenia, and the severity of the disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - complications</subject><subject>Brief Report</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Young Adult</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kUtPAyEYRYnR2Fr9AW4MiRs3KDAUmKWpz6SJG10TZmAcmnkJjNp_L7VqjIkbWHDu4ct3ATgm-JxgLC5COrlAmDBEBckQ3gFTwjKG8pzlu2CKhcAoI7mcgIMQVhhjKnOyDyaU5ZRxLKbgjc5RvTa-f1_DVxd16zp4BXVnoIsBetvo6Pou1G6Aby7WsGxc50rdfCKNLnqvY-_XcNBetzZaH2AyDClluyT4zPjajm3CnIHax9q76MIh2Kt0E-zR1z0DTzfXj4s7tHy4vV9cLlHJGI1IsEJWpakoLpi2vKqMKeZEzgXXXFvDucjLwkrDDDHcSFxQRnFJZcEyKYXJshk423oH37-MNkTVulDaptGd7cegCJ9TlhYj84Se_kFX_ei7NF2imKQsrVYmimyp0vcheFupwbtW-7UiWG1aUdtWVGpFbVpROGVOvsxj0Vrzk_iuIQF0C4T01D1b_-vrf60fXRKZcw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Abourazzak, F. E.</creator><creator>Talbi, S.</creator><creator>Aradoini, N.</creator><creator>Berrada, K.</creator><creator>Keita, S.</creator><creator>Hazry, T.</creator><general>Springer London</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150201</creationdate><title>25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis</title><author>Abourazzak, F. E. ; Talbi, S. ; Aradoini, N. ; Berrada, K. ; Keita, S. ; Hazry, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-74b8fcdf20b4ae6ffddb518576a6aed6679cbe8d4d1d6d80b2420c28b43887d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - complications</topic><topic>Brief Report</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abourazzak, F. E.</creatorcontrib><creatorcontrib>Talbi, S.</creatorcontrib><creatorcontrib>Aradoini, N.</creatorcontrib><creatorcontrib>Berrada, K.</creatorcontrib><creatorcontrib>Keita, S.</creatorcontrib><creatorcontrib>Hazry, T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abourazzak, F. E.</au><au>Talbi, S.</au><au>Aradoini, N.</au><au>Berrada, K.</au><au>Keita, S.</au><au>Hazry, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>34</volume><issue>2</issue><spage>353</spage><epage>357</epage><pages>353-357</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>The objective of this study is to evaluate the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. We included patients with rheumatoid arthritis followed in Rheumatology Department of Hassan II University Hospital, Fez, Morocco. Patients suffering from liver and kidney insufficiency and those who had received vitamin D in the previous 12 months have been excluded. Statistical analysis was done using SPSS v 18. A bivariate analysis and logistic regression were used to identify factors associated with vitamin D deficiency. One hundred seventy patients were included with a mean age of 50 ± 12.1 [17–83] years, and a female predominance (88.1 %). All of our patients had hypovitaminosis D. The prevalence of 25(OH)-D insufficiency and deficiency was 64.5 and 35.5 % successively. In unadjusted analysis, vitamin D concentration was inversely associated with pain visual analog scale VAS score (
p
< 0.001), asthenia VAS (
p
< 0.001), morning stiffness (
p
= 0.03), number of tender joints (
p
= 0.004), number of swollen joints (
p
< 0.001), inflammatory markers (
p
= 0,012), Disease Activity Score (
p
= 0.009), physical disability using Health Assessment Questionnaire (HAQ) (
p
= 0.001), and severity of the disease (
p
< 0.001). After logistic regression persisted association with female sex (OR = 4.3, CI = [0.94 to 20.976],
p
= 0.05), asthenia VAS (OR = 1.029, CI = [1.011 to 1.046],
p
= 0.001), and with the severity of the disease (OR = 2.910, CI = [1.314–6.441],
p
= 0.008). The vitamin D deficiency is common in our patients with RA. This deficiency is associated with female sex, severe asthenia, and the severity of the disease.</abstract><cop>London</cop><pub>Springer London</pub><pmid>24924607</pmid><doi>10.1007/s10067-014-2713-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical rheumatology, 2015-02, Vol.34 (2), p.353-357 |
| issn | 0770-3198 1434-9949 |
| language | eng |
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| source | Springer Nature |
| subjects | Adolescent Adult Aged Aged, 80 and over Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications Brief Report Female Humans Male Medicine Medicine & Public Health Middle Aged Prevalence Rheumatology Severity of Illness Index Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - epidemiology Young Adult |
| title | 25-hydroxy vitamin D and its relationship with clinical and laboratory parameters in patients with rheumatoid arthritis |
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