A framework to understand the variations of PSD-95 expression in brain aging and in Alzheimer's disease

Highlights • Contradictory data about PSD-95 expression in aging and AD have been reported. • In rodent models of aging and Alzheimer, PSD-95 decreases with synaptic loss. • In environmental enrichment models, PSD-95 expression rather increases. • PSD-95 expression depends on degenerative and reacti...

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Bibliographic Details
Published in:Ageing research reviews 2014-11, Vol.18, p.86-94
Main Authors: Savioz, Armand, Leuba, Geneviève, Vallet, Philippe G
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age Factors
Aging - genetics
Aging - metabolism
Aging - pathology
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer Disease - psychology
Animals
Biological and medical sciences
Brain - metabolism
Brain - pathology
Brain - physiopathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Development. Metamorphosis. Moult. Ageing
Disks Large Homolog 4 Protein
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Genotype
Humans
Internal Medicine
Intracellular Signaling Peptides and Proteins - genetics
Intracellular Signaling Peptides and Proteins - metabolism
Medical sciences
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice, Transgenic
Models, Biological
Neurology
Organic mental disorders. Neuropsychology
Phenotype
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Highlights • Contradictory data about PSD-95 expression in aging and AD have been reported. • In rodent models of aging and Alzheimer, PSD-95 decreases with synaptic loss. • In environmental enrichment models, PSD-95 expression rather increases. • PSD-95 expression depends on degenerative and reactive or compensatory mechanisms. • These observations question the translation of rodent models to Alzheimer disease.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2014.09.004