A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves

A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyranosyl-(1 → 2)-4-O-acetyl-α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside, has been isolated from the leaves of Tipuana tipu (Benth.) Lillo growing in Egypt, along with three known flavonol glycosides,...

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Bibliographic Details
Published in:Natural product research 2015-03, Vol.29 (6), p.511-517
Main Authors: Amen, Yhiya M., Marzouk, Amani M., Zaghloul, Mona G., Afifi, Mohamed S.
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory
Anti-Inflammatory Agents - chemistry
Egypt
Fabaceae
Fabaceae - chemistry
Glycosides - chemistry
kaempferol tetraglycoside
Kaempferols - chemistry
Male
Molecular Structure
Plant Leaves - chemistry
Rats
Tipuana tipu
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Summary:A new acylated kaempferol glycoside, kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-O-[β-d-glucopyranosyl-(1 → 2)-4-O-acetyl-α-l-rhamnopyranosyl-(1 → 2)]-β-d-galactopyranoside, has been isolated from the leaves of Tipuana tipu (Benth.) Lillo growing in Egypt, along with three known flavonol glycosides, kaempferol 3-O-rutinoside, quercetin 3-O-rutinoside (rutin) and kaempferol 3-O-[α-l-rhamnopyranosyl-(1 → 6)]-[α-l-rhamnopyranosyl-(1 → 2]-β-d-glucopyranoside. Structure elucidation was achieved through different spectroscopic methods. Structure relationship with anti-inflammatory activity using carrageenin-induced rat paw oedema model is discussed.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.952233