Protocetraric acid: an excellent broad spectrum compound from the lichen Usnea albopunctata against medically important microbes

• Published in: Natural product research 2015-03, Vol.29 (6), p.574-577
• Main Authors: Nishanth, Kumar S., Sreerag, R.S., Deepa, I., Mohandas, C., Nambisan, Bala
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; antimicrobial activity; broad spectrum; Heterocyclic Compounds, 3-Ring - chemistry; Heterocyclic Compounds, 3-Ring - pharmacology; lichen; Microbial Sensitivity Tests; Molecular Structure; protocetraric acid; Usnea - chemistry
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2014.953500

The aim of this study was to investigate the antimicrobial property of the compounds present in the lichen Usnea albopunctata. Ethyl acetate extract of the lichen was purified by column chromatography to yield a major compound which was characterised by spectroscopic methods as protocetraric acid. In this study, protocetraric acid recorded significant broad spectrum antimicrobial property against medically important human pathogenic microbes. The prominent antibacterial activity was recorded against Salmonella typhi (0.5 μg/mL). Significant antifungal activity was recorded against Trichophyton rubrum (1 μg/mL), which is significantly better that the standard antifungal agent. Protocetraric acid is reported here for the first time from U. albopunctata. Thus the results of this study suggest that protocetraric acid has significant antimicrobial activities and has a strong potential to be developed as an antimicrobial drug against pathogenic microbes.