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Effect of mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita

Highlights • Transient muscle weakness, a frequent symptom of nondystrophic myotonias, can be measured by the transient compound muscle action potential depression. • Mexiletine, the currently preferred antimyotonic drug, efficiently reduces the transient compound muscle action potential depression....

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Bibliographic Details
Published in:Clinical neurophysiology 2015-02, Vol.126 (2), p.399-403
Main Authors: Lo Monaco, Mauro, D’Amico, Adele, Luigetti, Marco, Desaphy, Jean-François, Modoni, Anna
Format: Article
Language:English
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Summary:Highlights • Transient muscle weakness, a frequent symptom of nondystrophic myotonias, can be measured by the transient compound muscle action potential depression. • Mexiletine, the currently preferred antimyotonic drug, efficiently reduces the transient compound muscle action potential depression. • The 3 Hz prolonged low-rate repetitive nerve stimulation might be considered a helpful tool to objectively assess the anti-myotonic effect of drugs in myotonic patients.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.06.008