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Effect of mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita
Highlights • Transient muscle weakness, a frequent symptom of nondystrophic myotonias, can be measured by the transient compound muscle action potential depression. • Mexiletine, the currently preferred antimyotonic drug, efficiently reduces the transient compound muscle action potential depression....
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Published in: | Clinical neurophysiology 2015-02, Vol.126 (2), p.399-403 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • Transient muscle weakness, a frequent symptom of nondystrophic myotonias, can be measured by the transient compound muscle action potential depression. • Mexiletine, the currently preferred antimyotonic drug, efficiently reduces the transient compound muscle action potential depression. • The 3 Hz prolonged low-rate repetitive nerve stimulation might be considered a helpful tool to objectively assess the anti-myotonic effect of drugs in myotonic patients. |
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ISSN: | 1388-2457 1872-8952 |
DOI: | 10.1016/j.clinph.2014.06.008 |