Normative data and long-term test–retest reliability of the triple stimulation technique (TST) in multiple sclerosis

Highlights • The triple stimulation technique (TST) is an advanced technique to study neurophysiologic cortico-spinal tract integrity. • Longitudinal methodological properties of TST measures were examined in multiple sclerosis (MS) patients. Additionally healthy controls were examined for derivatio...

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Published in:Clinical neurophysiology 2015-02, Vol.126 (2), p.356-364
Main Authors: Hofstadt-van Oy, U, Keune, P.M, Muenssinger, J, Hagenburger, D, Oschmann, P
Format: Article
Language:English
Subjects:
Adult
Evoked Potentials, Motor - physiology
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Motor Cortex - physiopathology
Multiple sclerosis (MS)
Multiple Sclerosis - diagnosis
Multiple Sclerosis - physiopathology
Neurology
Reproducibility of Results
Statistics as Topic - methods
Statistics as Topic - standards
Test–retest reliability
Transcranial magnetic stimulation (TMS)
Transcranial Magnetic Stimulation - methods
Transcranial Magnetic Stimulation - standards
Triple stimulation technique (TST)
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Summary:Highlights • The triple stimulation technique (TST) is an advanced technique to study neurophysiologic cortico-spinal tract integrity. • Longitudinal methodological properties of TST measures were examined in multiple sclerosis (MS) patients. Additionally healthy controls were examined for derivation of normative data. • TST values of MS patients were abnormal, highly reliable and stable during a long-term follow-up, supporting the diagnostic utility and methodological robustness of TST parameters.
ISSN:1388-2457
1872-8952
DOI:10.1016/j.clinph.2014.05.032