Effect of ultrasound and stabilizers on nucleation kinetics of curcumin during liquid antisolvent precipitation

[Display omitted] •Nucleation kinetics of curcumin with ultrasound and additives was estimated.•Ultrasound reduces induction times and MSZW and increases nucleation rates.•Stabilizers increase induction times and MSZW and decrease nucleation rates.•The solid-liquid interfacial energies were in the r...

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Bibliographic Details
Published in:Ultrasonics sonochemistry 2015-05, Vol.24, p.114-122
Main Authors: Dalvi, Sameer V., Yadav, Manishkumar D.
Format: Article
Language:English
Subjects:
Chemical Precipitation
Curcumin
Curcumin - chemistry
Induction time
Interfacial energy
Kinetics
Metastable zone width
Phase Transition
Stabilizers
Ultrasonic Waves
Ultrasound
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Summary:[Display omitted] •Nucleation kinetics of curcumin with ultrasound and additives was estimated.•Ultrasound reduces induction times and MSZW and increases nucleation rates.•Stabilizers increase induction times and MSZW and decrease nucleation rates.•The solid-liquid interfacial energies were in the range of 1.5–3.5mJ/m2. Nucleation kinetics of liquid antisolvent precipitation of a poorly water soluble drug curcumin in presence of ultrasound and surfactants have been estimated. Ultrasound and stabilizers were found to have opposing effects on induction time (τind), metastable zone width (MSZW) and nucleation rates (J) of curcumin during antisolvent precipitation. The use of ultrasound (in presence or absence of stabilizers) was found to decrease τind and MSZW drastically while the values of nucleation rates were found to increase. In contrast to these observations, use of stabilizers (in presence or absence of ultrasound) were found to increase MSZW, increase τind and lower the nucleation rates (J) of curcumin. The solid–liquid interfacial energies (γSL) for curcumin in aqueous ethanolic solutions (with and without stabilizers) have also been calculated using experimentally estimated induction time (τind) and supersaturation data. The values of solid–liquid interfacial energies were found to be in the range of 1.5–3.5mJ/m2. In comparison to these values, the values of γSL predicted by Mersmann equation and equation proposed by Bennema and Sohnel were found to be significantly higher and were in the range of 10–30mJ/m2.
ISSN:1350-4177
1873-2828
DOI:10.1016/j.ultsonch.2014.11.016