Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising bec...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2014-12, Vol.37 (12), p.721-732
Main Authors: Zempel, Hans, Mandelkow, Eckhard
Format: Article
Language:English
Subjects:
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer's disease
Animals
Axons - metabolism
Axons - pathology
Cytoskeleton
Cytoskeleton - metabolism
Cytoskeleton - pathology
Disease Models, Animal
Humans
Neurology
Neurons
Neurons - metabolism
Neurons - pathology
Neurosciences
Phosphorylation
tau Proteins - genetics
tau Proteins - metabolism
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Summary:Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2014.08.004