Loading…

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising bec...

Full description

Saved in:

Bibliographic Details
Published in:	Trends in neurosciences (Regular ed.) 2014-12, Vol.37 (12), p.721-732
Main Authors:	Zempel, Hans, Mandelkow, Eckhard
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Axons - metabolism Axons - pathology Cytoskeleton Cytoskeleton - metabolism Cytoskeleton - pathology Disease Models, Animal Humans Neurology Neurons Neurons - metabolism Neurons - pathology Neurosciences Phosphorylation tau Proteins - genetics tau Proteins - metabolism
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33
cites	cdi_FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33
container_end_page	732
container_issue	12
container_start_page	721
container_title	Trends in neurosciences (Regular ed.)
container_volume	37
creator	Zempel, Hans Mandelkow, Eckhard
description	Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.
doi_str_mv	10.1016/j.tins.2014.08.004
format	article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652407577</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166223614001313</els_id><sourcerecordid>3540316371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhoNY7G31D7iQgBs3M-ZjPjIiQin1Ay50YYXuQiY5o7nOTWpORmh_vRluVeiiq0B4zps3zyHkJWc1Z7x7u6uzD1gLxpuaqZqx5gnZcNWrijN1_ZRsCtRVQsjumJwg7lgBFW-ekWPRltue8Q253kbM1EwZEs3JBJxN9jG8o3uPGFN54DuNE70yC71JMYMP1ARHbQwIvxYIFpBOMdGz-e4H-H1JcR7BIDwnR5OZEV7cn6fk28eLq_PP1fby05fzs21lW9bmSjABVrVT54QbWWflKDhAA0aCUq6VknM3TsOogBVqWG9FLxrj7NAOYpLylLw55JZ6pRBmXZpbmGcTIC6oedeKhvVt3xf09QN0F5cUSrtCNWxQUklRKHGgbIqICSZ9k_zepFvNmV69651evevVu2ZKF-9l6NV99DLuwf0b-Su6AO8PABQXvz0kjdav-pxPYLN20T-e_-HBuJ198NbMP-EW8P8_NArN9Nd18-vieVOWLrmUfwAG2Kjb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1640983832</pqid></control><display><type>article</type><title>Lost after translation: missorting of Tau protein and consequences for Alzheimer disease</title><source>Elsevier</source><creator>Zempel, Hans ; Mandelkow, Eckhard</creator><creatorcontrib>Zempel, Hans ; Mandelkow, Eckhard</creatorcontrib><description>Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2014.08.004</identifier><identifier>PMID: 25223701</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer's disease ; Animals ; Axons - metabolism ; Axons - pathology ; Cytoskeleton ; Cytoskeleton - metabolism ; Cytoskeleton - pathology ; Disease Models, Animal ; Humans ; Neurology ; Neurons ; Neurons - metabolism ; Neurons - pathology ; Neurosciences ; Phosphorylation ; tau Proteins - genetics ; tau Proteins - metabolism</subject><ispartof>Trends in neurosciences (Regular ed.), 2014-12, Vol.37 (12), p.721-732</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Sequoia S.A. Dec 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33</citedby><cites>FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25223701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zempel, Hans</creatorcontrib><creatorcontrib>Mandelkow, Eckhard</creatorcontrib><title>Lost after translation: missorting of Tau protein and consequences for Alzheimer disease</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.</description><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Axons - metabolism</subject><subject>Axons - pathology</subject><subject>Cytoskeleton</subject><subject>Cytoskeleton - metabolism</subject><subject>Cytoskeleton - pathology</subject><subject>Disease Models, Animal</subject><subject>Humans</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Neurosciences</subject><subject>Phosphorylation</subject><subject>tau Proteins - genetics</subject><subject>tau Proteins - metabolism</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFTEUhoNY7G31D7iQgBs3M-ZjPjIiQin1Ay50YYXuQiY5o7nOTWpORmh_vRluVeiiq0B4zps3zyHkJWc1Z7x7u6uzD1gLxpuaqZqx5gnZcNWrijN1_ZRsCtRVQsjumJwg7lgBFW-ekWPRltue8Q253kbM1EwZEs3JBJxN9jG8o3uPGFN54DuNE70yC71JMYMP1ARHbQwIvxYIFpBOMdGz-e4H-H1JcR7BIDwnR5OZEV7cn6fk28eLq_PP1fby05fzs21lW9bmSjABVrVT54QbWWflKDhAA0aCUq6VknM3TsOogBVqWG9FLxrj7NAOYpLylLw55JZ6pRBmXZpbmGcTIC6oedeKhvVt3xf09QN0F5cUSrtCNWxQUklRKHGgbIqICSZ9k_zepFvNmV69651evevVu2ZKF-9l6NV99DLuwf0b-Su6AO8PABQXvz0kjdav-pxPYLN20T-e_-HBuJ198NbMP-EW8P8_NArN9Nd18-vieVOWLrmUfwAG2Kjb</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Zempel, Hans</creator><creator>Mandelkow, Eckhard</creator><general>Elsevier Ltd</general><general>Elsevier Sequoia S.A</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Lost after translation: missorting of Tau protein and consequences for Alzheimer disease</title><author>Zempel, Hans ; Mandelkow, Eckhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Axons - metabolism</topic><topic>Axons - pathology</topic><topic>Cytoskeleton</topic><topic>Cytoskeleton - metabolism</topic><topic>Cytoskeleton - pathology</topic><topic>Disease Models, Animal</topic><topic>Humans</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Neurosciences</topic><topic>Phosphorylation</topic><topic>tau Proteins - genetics</topic><topic>tau Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zempel, Hans</creatorcontrib><creatorcontrib>Mandelkow, Eckhard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zempel, Hans</au><au>Mandelkow, Eckhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lost after translation: missorting of Tau protein and consequences for Alzheimer disease</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><addtitle>Trends Neurosci</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>37</volume><issue>12</issue><spage>721</spage><epage>732</epage><pages>721-732</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><coden>TNSCDR</coden><abstract>Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25223701</pmid><doi>10.1016/j.tins.2014.08.004</doi><tpages>12</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0166-2236
ispartof	Trends in neurosciences (Regular ed.), 2014-12, Vol.37 (12), p.721-732
issn	0166-2236 1878-108X
language	eng
recordid	cdi_proquest_miscellaneous_1652407577
source	Elsevier
subjects	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Animals Axons - metabolism Axons - pathology Cytoskeleton Cytoskeleton - metabolism Cytoskeleton - pathology Disease Models, Animal Humans Neurology Neurons Neurons - metabolism Neurons - pathology Neurosciences Phosphorylation tau Proteins - genetics tau Proteins - metabolism
title	Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T12%3A12%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lost%20after%20translation:%20missorting%20of%20Tau%20protein%20and%20consequences%20for%20Alzheimer%20disease&rft.jtitle=Trends%20in%20neurosciences%20(Regular%20ed.)&rft.au=Zempel,%20Hans&rft.date=2014-12-01&rft.volume=37&rft.issue=12&rft.spage=721&rft.epage=732&rft.pages=721-732&rft.issn=0166-2236&rft.eissn=1878-108X&rft.coden=TNSCDR&rft_id=info:doi/10.1016/j.tins.2014.08.004&rft_dat=%3Cproquest_cross%3E3540316371%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c505t-202ec85f6d2db06c3b21ee4ea3e88d53311dbf9b8e085f93e882724adc9592f33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1640983832&rft_id=info:pmid/25223701&rfr_iscdi=true