Dietary nitrate supplementation in COPD: An acute, double-blind, randomized, placebo-controlled, crossover trial

•Beetroot juice is a rich source of dietary nitrate.•Acute consumption of beetroot juice was associated with increased exercise capacity among COPD subjects.•Serum nitrate and nitrite increased significantly after dietary nitrate only.•Similarly, blood pressure decreased significantly after dietary...

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Bibliographic Details
Published in:Nitric oxide 2015-01, Vol.44, p.105-111
Main Authors: Kerley, Conor P., Cahill, Kathleen, Bolger, Kenneth, McGowan, Aisling, Burke, Conor, Faul, John, Cormican, Liam
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Beetroot
Blood Pressure - drug effects
COPD
Cross-Over Studies
Dietary nitrate
Double-Blind Method
Exercise Test - drug effects
Exercise tolerance
Female
Hemodynamics - drug effects
Humans
Male
Middle Aged
Nitrates - administration & dosage
Nitrates - blood
Nitric oxide
Nitric Oxide - blood
Nitrite
Nitrites - blood
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - diet therapy
Pulmonary Disease, Chronic Obstructive - physiopathology
Walking
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Summary:•Beetroot juice is a rich source of dietary nitrate.•Acute consumption of beetroot juice was associated with increased exercise capacity among COPD subjects.•Serum nitrate and nitrite increased significantly after dietary nitrate only.•Similarly, blood pressure decreased significantly after dietary nitrate only.•The clinical application of dietary nitrate in COPD requires further study. The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity. We hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects. Eleven COPD subjects were randomly assigned to consume either a high nitrate or a matched, low nitrate beverage in a double-blind, randomized, placebo-controlled, crossover design. ISWT distance was measured both before and 3 h after the beverage and change was recorded. After a 7-day washout, ISWT distances were re-measured before and 3 h after the alternate beverage and changes were recorded. We observed an increase in ISWT distance after consuming the high nitrate juice (25 m) compared with a reduction after the low nitrate juice (14 m) (p 
ISSN:1089-8603
1089-8611
DOI:10.1016/j.niox.2014.12.010