Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family

• Published in: International journal of dermatology 2015-02, Vol.54 (2), p.174-178
• Main Authors: Akoğlu, Gülşen, Metin, Ahmet, Ceylan, Gülay Güleç, Emre, Selma, Akpolat, Demet, Süngü, Nuran
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Alleles; Apoptosis; Child; Female; Focal Epithelial Hyperplasia - genetics; Focal Epithelial Hyperplasia - pathology; Focal Epithelial Hyperplasia - virology; Genetic Predisposition to Disease - genetics; HLA-DQ alpha-Chains - genetics; HLA-DQ beta-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; Keratinocytes - cytology; Male; Papillomaviridae; Papillomavirus Infections - complications; Turkey
• ISSN: 0011-9059; 1365-4632
• DOI: 10.1111/ijd.12538

Background Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types. Methods HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction. Results Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them. Conclusion This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.