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Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family
Background Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen syst...
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| Published in: | International journal of dermatology 2015-02, Vol.54 (2), p.174-178 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4338-c1820593ad277553755779c833f26268cd8a3de23f9843317ad8333e57c9b4513 |
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| cites | cdi_FETCH-LOGICAL-c4338-c1820593ad277553755779c833f26268cd8a3de23f9843317ad8333e57c9b4513 |
| container_end_page | 178 |
| container_issue | 2 |
| container_start_page | 174 |
| container_title | International journal of dermatology |
| container_volume | 54 |
| creator | Akoğlu, Gülşen Metin, Ahmet Ceylan, Gülay Güleç Emre, Selma Akpolat, Demet Süngü, Nuran |
| description | Background
Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types.
Methods
HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction.
Results
Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them.
Conclusion
This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH. |
| doi_str_mv | 10.1111/ijd.12538 |
| format | article |
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Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types.
Methods
HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction.
Results
Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them.
Conclusion
This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.12538</identifier><identifier>PMID: 24738569</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Alleles ; Apoptosis ; Child ; Female ; Focal Epithelial Hyperplasia - genetics ; Focal Epithelial Hyperplasia - pathology ; Focal Epithelial Hyperplasia - virology ; Genetic Predisposition to Disease - genetics ; HLA-DQ alpha-Chains - genetics ; HLA-DQ beta-Chains - genetics ; HLA-DRB1 Chains - genetics ; Humans ; Keratinocytes - cytology ; Male ; Papillomaviridae ; Papillomavirus Infections - complications ; Turkey</subject><ispartof>International journal of dermatology, 2015-02, Vol.54 (2), p.174-178</ispartof><rights>2014 The International Society of Dermatology</rights><rights>2014 The International Society of Dermatology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-c1820593ad277553755779c833f26268cd8a3de23f9843317ad8333e57c9b4513</citedby><cites>FETCH-LOGICAL-c4338-c1820593ad277553755779c833f26268cd8a3de23f9843317ad8333e57c9b4513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24738569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akoğlu, Gülşen</creatorcontrib><creatorcontrib>Metin, Ahmet</creatorcontrib><creatorcontrib>Ceylan, Gülay Güleç</creatorcontrib><creatorcontrib>Emre, Selma</creatorcontrib><creatorcontrib>Akpolat, Demet</creatorcontrib><creatorcontrib>Süngü, Nuran</creatorcontrib><title>Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types.
Methods
HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction.
Results
Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them.
Conclusion
This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Apoptosis</subject><subject>Child</subject><subject>Female</subject><subject>Focal Epithelial Hyperplasia - genetics</subject><subject>Focal Epithelial Hyperplasia - pathology</subject><subject>Focal Epithelial Hyperplasia - virology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>HLA-DQ alpha-Chains - genetics</subject><subject>HLA-DQ beta-Chains - genetics</subject><subject>HLA-DRB1 Chains - genetics</subject><subject>Humans</subject><subject>Keratinocytes - cytology</subject><subject>Male</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Turkey</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kE9v1DAQxS0EokvhwBdAPsIhbeyJ8-eIFrYUVQWkAkdr6kxYd5042AklZ744LrvtjZGsGWt-70nzGHsp8hOR6tTetCdCKqgfsZWAUmVFCfIxW-W5EFmTq-aIPYvxJn1BiuIpO5JFBbUqmxX7s_EGHafRTltyNo3bZaQwOowWOcbojcWJWn6bAL6dexz4iKN1zvf4y4Y5cgEch5Yb3_d-OCCO5p03y0RpNdkfNHB0jhxFbtPIr-aws3HLO-ytW56zJx26SC8O_Zh93by_Wn_ILj6dna_fXmSmAKgzI2qZbgFsZVUpBelVVWNqgE6WsqxNWyO0JKFr6iQQFbZpB6Qq01wXSsAxe733HYP_OVOcdG-jIedwID9HLUoli7scm4S-2aMm-BgDdXoMtsewaJHru8x1ylz_yzyxrw6283VP7QN5H3ICTvfArXW0_N9Jn398d2-Z7RU2TvT7QYFhp8sqHa6_X57pb5-b9ZfqEvQG_gIuHJrY</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Akoğlu, Gülşen</creator><creator>Metin, Ahmet</creator><creator>Ceylan, Gülay Güleç</creator><creator>Emre, Selma</creator><creator>Akpolat, Demet</creator><creator>Süngü, Nuran</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family</title><author>Akoğlu, Gülşen ; Metin, Ahmet ; Ceylan, Gülay Güleç ; Emre, Selma ; Akpolat, Demet ; Süngü, Nuran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-c1820593ad277553755779c833f26268cd8a3de23f9843317ad8333e57c9b4513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alleles</topic><topic>Apoptosis</topic><topic>Child</topic><topic>Female</topic><topic>Focal Epithelial Hyperplasia - genetics</topic><topic>Focal Epithelial Hyperplasia - pathology</topic><topic>Focal Epithelial Hyperplasia - virology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>HLA-DQ alpha-Chains - genetics</topic><topic>HLA-DQ beta-Chains - genetics</topic><topic>HLA-DRB1 Chains - genetics</topic><topic>Humans</topic><topic>Keratinocytes - cytology</topic><topic>Male</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akoğlu, Gülşen</creatorcontrib><creatorcontrib>Metin, Ahmet</creatorcontrib><creatorcontrib>Ceylan, Gülay Güleç</creatorcontrib><creatorcontrib>Emre, Selma</creatorcontrib><creatorcontrib>Akpolat, Demet</creatorcontrib><creatorcontrib>Süngü, Nuran</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akoğlu, Gülşen</au><au>Metin, Ahmet</au><au>Ceylan, Gülay Güleç</au><au>Emre, Selma</au><au>Akpolat, Demet</au><au>Süngü, Nuran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2015-02</date><risdate>2015</risdate><volume>54</volume><issue>2</issue><spage>174</spage><epage>178</epage><pages>174-178</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Focal epithelial hyperplasia (FEH) is a rare and benign papillomatous disease of the oral cavity, which is closely associated with human papillomavirus (HPV) type 13 and 32. Genetic susceptibility to HPV infections are supported by recent studies involving the human leukocyte antigen system (HLA). In this report, we aimed to determine the clinicopathological features of a Turkish family with FEH and to detect the shared HLA DR and DQ types.
Methods
HPV DNA typing of tissue samples and HLA determination from blood samples of four family members were performed by polymerase chain reaction.
Results
Histopathological examination of all patients revealed acanthotic papillomatous epidermis, koilocytes, apoptotic keratinocytes, and mitosoid bodies. HPV13 was detected by polymerase chain reaction. HLA DQA1*0501, HLA DQB1*0302, and HLA DRB1*11 alleles were common in all family members. HLA DRB1*04 was detected in three of them.
Conclusion
This report is the first step for the investigation of involvement of HLA types in the pathogenesis of Turkish patients with FEH.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24738569</pmid><doi>10.1111/ijd.12538</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of dermatology, 2015-02, Vol.54 (2), p.174-178 |
| issn | 0011-9059 1365-4632 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adolescent Adult Alleles Apoptosis Child Female Focal Epithelial Hyperplasia - genetics Focal Epithelial Hyperplasia - pathology Focal Epithelial Hyperplasia - virology Genetic Predisposition to Disease - genetics HLA-DQ alpha-Chains - genetics HLA-DQ beta-Chains - genetics HLA-DRB1 Chains - genetics Humans Keratinocytes - cytology Male Papillomaviridae Papillomavirus Infections - complications Turkey |
| title | Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family |
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