Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer

Highlights • In this mini review we describe the functional roles of lactate dehydrogenase 5 (Ldh-5) in the development of cancer. • We show diagnostic and prognostic significance of total LDH activity and LDH isoform patterns in neoplastic diseases. • We describe LDH-5 as a promising therapeutic ta...

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Bibliographic Details
Published in:Cancer letters 2015-03, Vol.358 (1), p.1-7
Main Authors: Augoff, Katarzyna, Hryniewicz-Jankowska, Anita, Tabola, Renata
Format: Article
Language:English
Subjects:
Aerobic glycolysis
Binding sites
Breast cancer
Cancer metabolism
Cancer therapies
Carcinogenesis - genetics
Citric Acid Cycle - genetics
Dehydrogenases
Deoxyribonucleic acid
DNA
Gene expression
Gene Expression Regulation, Neoplastic
Glycolysis - genetics
Hematology, Oncology and Palliative Medicine
Humans
Hypoxia
Isoenzymes - biosynthesis
Isoenzymes - genetics
Isoenzymes - metabolism
Kinases
L-Lactate Dehydrogenase - biosynthesis
L-Lactate Dehydrogenase - genetics
L-Lactate Dehydrogenase - metabolism
Lactate dehydrogenase 5 (LDH-5)
Medical prognosis
Metabolism
Metastasis
Molecular Targeted Therapy
Neoplasms - enzymology
Neoplasms - pathology
Neoplasms - therapy
Phosphorylation
Proteins
Radiation therapy
Signal transduction
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Summary:Highlights • In this mini review we describe the functional roles of lactate dehydrogenase 5 (Ldh-5) in the development of cancer. • We show diagnostic and prognostic significance of total LDH activity and LDH isoform patterns in neoplastic diseases. • We describe LDH-5 as a promising therapeutic target for cancer treatment. • We summarize novel synthetic and natural products with LDH-5 inhibitory properties and discuss their therapeutic potential.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.12.035