Mechanisms of endothelial cell protection by hydroxycinnamic acids

Abstract An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant pol...

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Bibliographic Details
Published in:Vascular pharmacology 2014-12, Vol.63 (3), p.155-161
Main Authors: Fuentes, Eduardo, Palomo, Iván
Format: Article
Language:English
Subjects:
Animals
Cardiovascular
Coumaric Acids - pharmacology
Endothelial Cells - drug effects
Endothelium
Endothelium, Vascular - drug effects
Humans
Hydroxycinnamic acids
NF-κB pathway
Protective Agents - pharmacology
Thrombosis
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Summary:Abstract An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as they are present in high levels in many widely consumed foods, such as fruit, vegetables and beverages. Therefore, it can be established that due to the hydroxycinnamic acid content (caffeic, chlorogenic, feluric and p -coumaric acids), fruit, vegetables and beverages contribute to endothelial protection (attenuates oxidative stress, improved nitric oxide bioavailability and decreased E-selectin, ICAM-1 and VCAM-1 expression, among others). In this article, we systematically examine the mechanisms of endothelium protection of hydroxycinnamic acids.
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2014.10.006