The interaction between cytomegalovirus and the human immune system

Abstract Studies on antiviral immunity in man are hampered by the impossibility to standardize the infection as is done in experimental animal studies. An exception is the occurrence of cytomegalovirus infection transmitted by a donor organ into a transplant-recipient, where the time-point of infect...

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Bibliographic Details
Published in:Immunology letters 2014-12, Vol.162 (2), p.141-144
Main Authors: ten Berge, Ineke J.M, van Lier, René A.W
Format: Article
Language:English
Subjects:
Allergy and Immunology
antiviral immunity
CD8 cells
CMV
cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus Infections - immunology
Cytomegalovirus Infections - therapy
Cytomegalovirus Infections - transmission
Cytomegalovirus Vaccines - immunology
Cytomegalovirus Vaccines - therapeutic use
Female
Humans
Male
Netherlands
Organ Transplantation
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Summary:Abstract Studies on antiviral immunity in man are hampered by the impossibility to standardize the infection as is done in experimental animal studies. An exception is the occurrence of cytomegalovirus infection transmitted by a donor organ into a transplant-recipient, where the time-point of infection is exactly known. Moreover, its strong interaction with the human immune system during evolution and the strong immunogenic properties of this persistent virus, as well as the need for intervention e.g. by vaccine development, all make studies towards the immune response against just this virus very attractive and relevant. In this work, we will present an overview of the studies on this topic that were performed in the departments of Experimental and Clinical Immunology in the AMC and Sanquin in Amsterdam.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2014.10.009