Measurement, analysis and prediction of topical UV filter bioavailability

[Display omitted] The aim of the present study was to objectively quantify and predict bioavailability of three sunscreen agents (i.e., benzophenone-3, 2-ethylhexylsalicylate, and 2 ethylhexyl-4-methoxycinnamate) in epidermis treated by petrolatum and emulsion-based formulations for 7 and 30min on f...

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Bibliographic Details
Published in:International journal of pharmaceutics 2015-01, Vol.478 (2), p.804-810
Main Authors: Roussel, L., Gilbert, E., Salmon, D., Serre, C., Gabard, B., Haftek, M., Maibach, H.I., Pirot, F.
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Aged
Benzophenones - pharmacokinetics
Bioequivalence
Biological Availability
Chemical UV filters
Cinnamates - pharmacokinetics
Dermatopharmacokinetics
Humans
Middle Aged
Salicylates - pharmacokinetics
Skin - metabolism
Skin Absorption
Sunscreening Agents - pharmacokinetics
Topical bioavailability
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Summary:[Display omitted] The aim of the present study was to objectively quantify and predict bioavailability of three sunscreen agents (i.e., benzophenone-3, 2-ethylhexylsalicylate, and 2 ethylhexyl-4-methoxycinnamate) in epidermis treated by petrolatum and emulsion-based formulations for 7 and 30min on four human volunteers. Profiles of sunscreen agents through stratum corneum (SC), derived from the assessment of chemical amounts in SC layers collected by successive adhesive tape-stripping, were successfully fitted to Fick’s second law of diffusion. Therefore, permeability coefficients of sunscreen agents were found lower with petrolatum than with emulsion based formulations confirming the crucial role of vehicle in topical delivery. Furthermore, the robustness of that methodology was confirmed by the linear relationship between the chemical absorption measured after 30min and that predicted from the 7-min exposure experiment. Interestingly, in this dermatopharmacokinetic method, the deconvolution of permeability coefficients in their respective partition coefficients and absorption constants allowed a better understanding of vehicle effects upon topical bioavailability mechanisms and bioequivalence of skin products.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.12.026