Fatty acids in cell signaling: Historical perspective and future outlook

Abstract Fatty acids are not only important metabolic substrates and building blocks of lipids but are also increasingly being recognized for their modulatory roles in a wide variety of cellular processes including gene expression, together referred to as the ‘message-modulator’ function of fatty ac...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2015-01, Vol.92, p.57-62
Main Authors: Glatz, Jan F.C, Luiken, Joost J.F.P
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
Biological Transport
Cell Membrane - metabolism
Endocrinology & Metabolism
Fatty Acids - physiology
Humans
Lipid Metabolism
Signal Transduction
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Summary:Abstract Fatty acids are not only important metabolic substrates and building blocks of lipids but are also increasingly being recognized for their modulatory roles in a wide variety of cellular processes including gene expression, together referred to as the ‘message-modulator’ function of fatty acids. Crucial for this latter role is the bioavailability of fatty acids, which is governed by their interaction with soluble proteins capable of binding fatty acids, i.e., plasma albumin and cytoplasmic fatty acid-binding protein (FABPc ), and with both the lipid and protein components of biological membranes, including membrane-associated fatty acid-binding proteins such as the transmembrane protein CD36. Manipulating fatty acid availability holds promise as therapeutic approach for chronic diseases that are characterized by a perturbed fatty acid metabolism.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2014.02.007