Influence of diabetes mellitus on tissue response to MTA and its ability to stimulate mineralization

Aim To evaluate the influence of diabetes mellitus on the tissue response to mineral trioxide aggregate (MTA) and its ability to stimulate mineralization. Methods Twenty‐four male Wistar rats were divided into a non‐diabetic control group and another with Alloxan‐induced diabetes. Two polyethylene t...

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Published in:Dental traumatology 2015-02, Vol.31 (1), p.67-72
Main Authors: Gomes-Filho, João Eduardo, de Azevedo Queiroz, Índia Olinta, Watanabe, Simone, da Silva Santos, Ludmilla Mota, Lodi, Carolina Simonetti, Okamoto, Robertta, Ervolino, Edilson, Dezan Jr, Elói, Cintra, Luciano Tavares Angelo
Format: Article
Language:English
Subjects:
Aluminum Compounds - pharmacology
Animals
biocompatibility
Biocompatible Materials
Calcium Compounds - pharmacology
Dentistry
diabetes mellitus
Diabetes Mellitus, Experimental
Drug Combinations
endodontics
Inflammation - chemically induced
Male
Materials Testing
Microscopy, Fluorescence
MTA
Necrosis
Oxides - pharmacology
Polyethylene
Rats
Rats, Wistar
Silicates - pharmacology
Subcutaneous Tissue - drug effects
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Summary:Aim To evaluate the influence of diabetes mellitus on the tissue response to mineral trioxide aggregate (MTA) and its ability to stimulate mineralization. Methods Twenty‐four male Wistar rats were divided into a non‐diabetic control group and another with Alloxan‐induced diabetes. Two polyethylene tubes, one kept empty as a control and the other containing Angelus MTA®, were implanted into the dorsal connective tissue of all rats for 30 days. Animals in each group received injections of calcein, alizarin, and oxytetracycline on day 7, 14, and 21, respectively. Animals were killed after 30 days; specimens were prepared by staining with hematoxylin and eosin (HE) and von Kossa technique as well as for examination of unstained sections with polarized light and fluorescence microscopy. Results The inflammatory reaction to the implanted tubes was equally mild in both groups. Structures staining with von Kossa were seen in response to Angelus MTA®, as were birefringent structures visualized on polarized light analysis; these had no relation to diabetic condition (P 
ISSN:1600-4469
1600-9657
DOI:10.1111/edt.12130