Clinicopathological features and prognosis of gastric cardia adenocarcinoma: A multi-institutional U.S. study

Background and Objectives Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and non‐cardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non‐cardia ade...

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Published in:Journal of surgical oncology 2015-03, Vol.111 (3), p.285-292
Main Authors: Amini, Neda, Spolverato, Gaya, Kim, Yuhree, Squires, Malcolm H., Poultsides, George A., Fields, Ryan, Schmidt, Carl, Weber, Sharon M., Votanopoulos, Konstantinos, Maithel, Shishir K., Pawlik, Timothy M.
Format: Article
Language:English
Subjects:
Adenocarcinoma - epidemiology
Adenocarcinoma - mortality
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Aged
Cardia - pathology
Cardia - surgery
Case-Control Studies
Female
Follow-Up Studies
Gastrectomy
gastric adenocarcinoma
gastric cardia cancer
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Grading
Neoplasm Staging
outcomes
Prognosis
Stomach Neoplasms - epidemiology
Stomach Neoplasms - mortality
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
surgery
Survival Rate
United States - epidemiology
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Summary:Background and Objectives Potential differences in presentation and outcome of patients with gastric cardia adenocarcinoma (GCA) and non‐cardia adenocarcinoma may exist. The aim of the present study was to compare the clinicopathological characteristics and the prognosis of GCA versus non‐cardia adenocarcinoma. Method Patients with gastric adenocarcinoma who underwent gastric resection between 2000–2012 were identified. Clinicopathological characteristics and outcomes were analyzed based on tumor site using a 1:2 matched‐control, as well as a multivariable Cox model. Results Among 743 patients, 80 (10.7%) patients were diagnosed with GCA. Patients with GCA were more likely to have intestinal tumor type (GCA: 80.4% versus non‐cardia: 64.2%, P = 0.04) or advanced AJCC T stage tumors (GCA 71.8% versus non‐cardia 59.2%, P = 0.03). GCA patients more likely underwent a total gastrectomy (GCA: 85.7% vs. non‐cardia: 39.8%) and had a longer length‐of‐stay (GCA: 10 days vs. non‐cardia: 8 days) (both P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.23799