Differential role of angiogenesis and tumour cell proliferation in brain metastases according to primary tumour type: analysis of 639 cases

Aim We aimed to characterize angiogenesis and proliferation and their correlation with clinical characteristics in a large brain metastasis (BM) series. Methods Ki67 proliferation index, microvascular density (MVD) and hypoxia‐inducible factor 1 alpha (HIF‐1 alpha) index were determined by immunohis...

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Published in:Neuropathology and applied neurobiology 2015-02, Vol.41 (2), p.e41-e55
Main Authors: Berghoff, Anna S., Ilhan-Mutlu, Aysegül, Dinhof, Carina, Magerle, Manuel, Hackl, Monika, Widhalm, Georg, Hainfellner, Johannes A., Dieckmann, Karin, Pichler, Josef, Hutterer, Markus, Melchardt, Thomas, Bartsch, Rupert, Zielinski, Christoph C., Birner, Peter, Preusser, Matthias
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angiogenesis
brain metastases
Brain Neoplasms - blood supply
Brain Neoplasms - mortality
Brain Neoplasms - secondary
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Cell Proliferation
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
HIF-1 alpha index
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - analysis
Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis
Immunohistochemistry
Kaplan-Meier Estimate
Ki-67 Antigen - analysis
ki67 proliferation index
Lung cancer
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Melanoma
Melanoma - mortality
Melanoma - pathology
microvascular density
Middle Aged
Neovascularization, Pathologic - mortality
Neovascularization, Pathologic - pathology
Proportional Hazards Models
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Summary:Aim We aimed to characterize angiogenesis and proliferation and their correlation with clinical characteristics in a large brain metastasis (BM) series. Methods Ki67 proliferation index, microvascular density (MVD) and hypoxia‐inducible factor 1 alpha (HIF‐1 alpha) index were determined by immunohistochemistry in BM and primary tumour specimens. Results Six hundred thirty‐nine BM specimens of 639 patients with lung cancer (344/639; 53.8%), breast cancer (105/639; 16.4%), melanoma (67/639; 10.5%), renal cell carcinoma (RCC; 52/639; 8.1%) or colorectal cancer (CRC; 71/639; 11.1%) were available. Specimens of the corresponding primary tumour were available in 113/639 (17.7%) cases. Median Ki67 index was highest in CRC BM and lowest in RCC BM (P 
ISSN:0305-1846
1365-2990
DOI:10.1111/nan.12185