Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies

Abstract Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180–199) peptide developed a chronic, sometimes relapsing–remitting type of disease. Our model fulfills electrophysiological c...

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Bibliographic Details
Published in:Journal of neuroimmunology 2015-01, Vol.278, p.1-10
Main Authors: Brun, Susana, Beaino, Wissam, Kremer, Laurent, Taleb, Omar, Mensah-Nyagan, Ayikoe Guy, Lam, Chanh D, Greer, Judith M, de Seze, Jérôme, Trifilieff, Elisabeth
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal model
Animals
Cell Proliferation - drug effects
Cell Proliferation - physiology
Chronic EAN
CIDP
Disease Models, Animal
Electrophysiology
Evoked Potentials - physiology
Immunology
Interleukin-17 - blood
Lymphocytes - metabolism
Lymphocytes - pathology
Macrophages - pathology
Male
Myelin P0 Protein - chemistry
Myelin P0 Protein - toxicity
Neurology
Peptides - toxicity
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - blood
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - chemically induced
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - physiopathology
Rats
Rats, Inbred Lew
Sciatic Nerve - pathology
Sciatic Nerve - physiopathology
Sciatic nerve immunohistochemistry
T-Lymphocytes - pathology
Thiopalmitoylated P0 peptide
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Summary:Abstract Our objective was to develop a chronic model of EAN which could be used as a tool to test treatment strategies for CIDP. Lewis rats injected with S-palmitoylated P0(180–199) peptide developed a chronic, sometimes relapsing–remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology. The late phase of the chronic disease was characterized by accumulation of IL-17+ cells and macrophages in sciatic nerves and by high serum IL-17 levels. In conclusion, we have developed a reliable and reproducible animal model resembling CIDP that can now be used for translational drug studies.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2014.11.022