One device, one equation: The simplest way to objectively evaluate psoriasis severity

The erythema, scale and thickness of psoriasis lesions could be converted to bioengineering parameters. An objective psoriasis severity assessment is advantageous in terms of accuracy and reproducibility over conventional severity assessment. We aimed to formulate an objective psoriasis severity ind...

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Bibliographic Details
Published in:Journal of dermatology 2015-02, Vol.42 (2), p.154-158
Main Authors: Choi, Jae Woo, Kim, Bo Ri, Choi, Chong Won, Youn, Sang Woong
Format: Article
Language:English
Subjects:
Bioengineering
Bioengineering - instrumentation
Colorimeter
Colorimetry
Drug therapy
Elasticity
Humans
Linear Models
Mathematical Concepts
objective
Psoriasis
Psoriasis - pathology
Psoriasis - physiopathology
Psoriasis Severity Index
Reproducibility of Results
Severity of Illness Index
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Summary:The erythema, scale and thickness of psoriasis lesions could be converted to bioengineering parameters. An objective psoriasis severity assessment is advantageous in terms of accuracy and reproducibility over conventional severity assessment. We aimed to formulate an objective psoriasis severity index with a single bioengineering device that can possibly substitute the conventional subjective Psoriasis Severity Index. A linear regression analysis was performed to derive the formula with the subjective Psoriasis Severity Index as the dependent variable and various bioengineering parameters determined from 157 psoriasis lesions as independent variables. The construct validity of the objective Psoriasis Severity Index was evaluated with an additional 30 psoriasis lesions through a Pearson correlation analysis. The formula is composed of hue and brightness, which are sufficiently obtainable with a Colorimeter alone. A very strong positive correlation was found between the objective and subjective psoriasis severity indexes. The objective Psoriasis Severity Index is a novel, practical and valid assessment method that can substitute the conventional one. Combined with subjective area assessment, it could further replace the Psoriasis Area and Severity Index which is currently most popular.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.12727