Expression of WT‐1 by the vascular component of acral pseudolymphomatous angiokeratoma of children

• Published in: Journal of cutaneous pathology 2015-01, Vol.42 (1), p.50-55
• Main Authors: Fernandez‐Flores, Angel, Fierro, Socorro, Larralde, Margarita
• Format: Article
• Language: English
• Subjects: acral angiokerathomatous pseudolymphoma; Angiokeratoma - blood supply; Angiokeratoma - metabolism; Angiokeratoma - pathology; APACHE; Blood Vessels - metabolism; Blood Vessels - pathology; Child, Preschool; Foot - blood supply; Foot - pathology; Humans; Immunohistochemistry; Male; papular angiolymphoid hyperplasia; Pseudolymphoma - metabolism; Pseudolymphoma - pathology; pseudolymphomatous angiokeratoma; Skin Neoplasms - blood supply; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; WT1 Proteins - blood
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.12429

Acral pseudolymphomatous angiokeratoma of children (APACHE) is a disease comprised by a dense dermal infiltrate of B‐lymphocytes and T‐lymphocytes in which prominent blood vessels with plump endothelium are found. In the past, the lesion was interpreted as a variant of angiokeratoma, a vascular malformation, or a nevus. Currently, most authors consider it to be a type of pseudolymphoma with prominent blood vessels. The latter express CD34 and D2‐40, while they lack the expression of Glut‐1. The expression of Wilms tumor‐1 (WT‐1) by APACHE has not yet been studied. In this report, we present a case of APACHE on the right foot of a 4‐year‐old boy and demonstrate immunoexpression of WT‐1 by the blood vessels of the lesion. We also performed serial sections and demonstrated that the WT‐1+ vessels with prominent endothelium were D2‐40−.