Clearance of depot vaccine SPIO-labeled antigen and substrate visualized using MRI

Highlights • Vaccine components were visualized longitudinally when tagged with iron oxide. • In vivo changes in biodistribution observed using magnetic resonance imaging (MRI). • Iron-labeled antigen in DepoVax exhibits sustained clearance from the vaccine site. • Sustained antigen clearance consis...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2014-12, Vol.32 (51), p.6956-6962
Main Authors: Brewer, Kimberly D, Lake, Kerry, Pelot, Nicole, Stanford, Marianne M, DeBay, Drew R, Penwell, Andrea, Weir, Genevieve M, Karkada, Mohan, Mansour, Marc, Bowen, Chris V
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Applied microbiology
Biological and medical sciences
Cancer
Clinical trials
Delayed-Action Preparations - administration & dosage
Delayed-Action Preparations - pharmacokinetics
Drug dosages
Female
Ferric Compounds - analysis
Fundamental and applied biological sciences. Psychology
Humans
Immunotherapy
Iron oxides
Lymphatic system
Lymphocytes
Magnetic Resonance Imaging
Medical sciences
Mice, Inbred C57BL
Microbiology
Migration
Miscellaneous
NMR
Nuclear magnetic resonance
Peptides
Studies
Tumors
Vaccines
Vaccines - administration & dosage
Vaccines - pharmacokinetics
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Vaccine components were visualized longitudinally when tagged with iron oxide. • In vivo changes in biodistribution observed using magnetic resonance imaging (MRI). • Iron-labeled antigen in DepoVax exhibits sustained clearance from the vaccine site. • Sustained antigen clearance consistent with active transport by immune cells.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.10.058