Experimental analysis of the mechanical behavior of the viscoelastic porcine pancreas and preliminary case study on the human pancreas

The aim of this article is to study the mechanical properties of the pancreas. Up to now, the mechanical properties of the pancreas are not sufficiently characterized. The possibility of intraoperative mechanical testing of pathological pancreata will allow the classification of pancreatic diseases...

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Bibliographic Details
Published in:Journal of the mechanical behavior of biomedical materials 2015-01, Vol.41, p.199-207
Main Authors: Wex, C., Fröhlich, M., Brandstädter, K., Bruns, C., Stoll, A.
Format: Article
Language:English
Subjects:
Animals
Assessments
Biomechanical Phenomena
Diseases
Elasticity
Human
Humans
Liver
Materials Testing
Mechanical properties
Organ Size
Pancreas
Pancreas - cytology
Pancreas Transplantation
Pancreatitis
Quality assessment
Shear
Shear Rheology
Soft tissue mechanics
Species Specificity
Swine
Viscoelasticity
Viscosity
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Summary:The aim of this article is to study the mechanical properties of the pancreas. Up to now, the mechanical properties of the pancreas are not sufficiently characterized. The possibility of intraoperative mechanical testing of pathological pancreata will allow the classification of pancreatic diseases in the future. The application of mechanical parameters instead of the intraoperative frozen section analysis shortens waiting times in the operating room. This study proves the general applicability of shear rheology for the determination of the mechanical properties of pancreas and the assessment of graft quality for transplantation. Porcine and human pancreas samples were examined ex vivo and a nonlinear viscoelastic behavior was observed. Pancreas was found to be more viscous than liver but both abdominal organs showed a similar flow behavior. The shear deformation dependence of healthy human pancreas was similar to porcine pancreas. An increase in the post-mortem time led to an increase in the complex modulus for a post-mortem time up to 8.5 days. Histological investigations showed that an increased amount of collagen coincides with the stiffening of the pancreatic tissue.
ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2014.10.013