Cytokinetic abscission: molecular mechanisms and temporal control

Cytokinesis mediates the physical separation of dividing cells after chromosome segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and myosin filaments, ingresses a cleavage furrow midway between the two spindle poles. A distinct machinery, involving the Endosomal...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2014-12, Vol.31 (5), p.525-538
Main Authors: Mierzwa, Beata, Gerlich, Daniel W.
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - metabolism
Actin Cytoskeleton - ultrastructure
Animals
Cell Membrane - metabolism
Cell Membrane - ultrastructure
Cell Proliferation - physiology
Chromosome Segregation - physiology
Cytokinesis - physiology
Endosomal Sorting Complexes Required for Transport - metabolism
Humans
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cytokinesis mediates the physical separation of dividing cells after chromosome segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and myosin filaments, ingresses a cleavage furrow midway between the two spindle poles. A distinct machinery, involving the Endosomal Sorting Complex Required for Transport III (ESCRT-III), subsequently splits the plasma membrane of nascent daughter cells in a process termed abscission. Here, we provide a brief overview of early cytokinesis events in animal cells and then cover in depth recently emerging models for the assembly and function of the abscission machinery and its temporal coordination with chromosome segregation.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2014.11.006